Další formáty:
BibTeX
LaTeX
RIS
@article{1305259,
author = {Bienertová Vašků, Julie and Novák, Jan and Vašků, Anna},
article_location = {New York},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.jash.2014.12.011},
keywords = {Hypoxia; lungs; non-coding RNAs; vascular remodeling},
language = {eng},
issn = {1933-1711},
journal = {Journal of the American Society of Hypertension},
title = {MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment},
url = {http://www.ashjournal.com/article/S1933-1711(14)00909-7/abstract},
volume = {9},
year = {2015}
}
TY - JOUR
ID - 1305259
AU - Bienertová Vašků, Julie - Novák, Jan - Vašků, Anna
PY - 2015
TI - MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment
JF - Journal of the American Society of Hypertension
VL - 9
IS - 3
SP - 221-234
EP - 221-234
PB - Elsevier Science Inc.
SN - 19331711
KW - Hypoxia
KW - lungs
KW - non-coding RNAs
KW - vascular remodeling
UR - http://www.ashjournal.com/article/S1933-1711(14)00909-7/abstract
L2 - http://www.ashjournal.com/article/S1933-1711(14)00909-7/abstract
N2 - Pulmonary arterial hypertension (PAH) is a severe and increasingly prevalent disease, manifested by the maladaptation of pulmonary vasculature, which consequently leads to right heart failure and possibly even death. The development of PAH is characterized by specific functional as well as structural changes, primarily associated with the aberrant function of the pulmonary artery endothelial cells, smooth muscle cells, and vascular fibroblasts. MicroRNAs constitute a class of small 22–nucleotides–long non–coding RNAs that post–transcriptionally regulate gene expression and that may lead to significant cell proteome changes. While the involvement of miRNAs in the development of various diseases—especially cancer—has been reported, numerous miRNAs have also been associated with PAH onset, progression, or treatment responsiveness. This review focuses on the role of microRNAs in the development of PAH as well as on their potential use as biomarkers and therapeutic tools in both experimental PAH models and in humans. Special attention is given to the roles of miR–21, miR–27a, the miR–17–92 cluster, miR–124, miR–138, the miR–143/145 cluster, miR–150, miR–190, miR–204, miR–206, miR–210, miR–328, and the miR–424/503 cluster, specifically with the objective of providing greater insight into the pervasive roles of miRNAs in the pathogenesis of this deadly condition.
ER -
BIENERTOVÁ VAŠKŮ, Julie, Jan NOVÁK a Anna VAŠKŮ. MicroRNAs in pulmonary arterial hypertension: pathogenesis, diagnosis and treatment. \textit{Journal of the American Society of Hypertension}. New York: Elsevier Science Inc., 2015, roč.~9, č.~3, s.~221-234. ISSN~1933-1711. Dostupné z: https://dx.doi.org/10.1016/j.jash.2014.12.011.
|
