Altered intensity coding in the salicylate-overdose animal
model of tinnitus

J 2015

Altered intensity coding in the salicylate-overdose animal model of tinnitus

WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ, Paul Waifung POON et. al.

Základní údaje

Originální název

Altered intensity coding in the salicylate-overdose animal model of tinnitus

Autoři

WAN, Ilynn (156 Čína), Ondřej POKORA (203 Česká republika, garant, domácí), Tzaiwen CHIU (156 Čína), Petr LÁNSKÝ (203 Česká republika) a Paul Waifung POON (156 Čína)

Vydání

BioSystems, ELSEVIER SCI LTD, 2015, 0303-2647

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10101 Pure mathematics

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.495

Kód RIV

RIV/00216224:14310/15:00083312

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.biosystems.2015.06.010

UT WoS

000366535200014

Klíčová slova anglicky

Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 24. 3. 2016 15:15, Ing. Andrea Mikešková

Anotace

V originále

Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions.

Citovat

WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ a Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. BioSystems. ELSEVIER SCI LTD, 2015, roč. 136, october, s. 113-119. ISSN 0303-2647. Dostupné z: https://dx.doi.org/10.1016/j.biosystems.2015.06.010.

@article{1305279,
   author = {Wan, Ilynn and Pokora, Ondřej and Chiu, Tzaiwen and Lánský, Petr and Poon, Paul Waifung},
   article_number = {october},
   doi = {http://dx.doi.org/10.1016/j.biosystems.2015.06.010},
   keywords = {Auditory evoked ponetial; Electrocorticogram; Fisher information; Salicylate-overdose; Tinnitus; Rat},
   language = {eng},
   issn = {0303-2647},
   journal = {BioSystems},
   title = {Altered intensity coding in the salicylate-overdose animal model of tinnitus},
   volume = {136},
   year = {2015}
}

TY  - JOUR
ID  - 1305279
AU  - Wan, Ilynn - Pokora, Ondřej - Chiu, Tzaiwen - Lánský, Petr - Poon, Paul Waifung
PY  - 2015
TI  - Altered intensity coding in the salicylate-overdose animal model of tinnitus
JF  - BioSystems
VL  - 136
IS  - october
SP  - 113-119
EP  - 113-119
PB  - ELSEVIER SCI LTD
SN  - 03032647
KW  - Auditory evoked ponetial
KW  - Electrocorticogram
KW  - Fisher information
KW  - Salicylate-overdose
KW  - Tinnitus
KW  - Rat
N2  - Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions.
ER  -

WAN, Ilynn, Ondřej POKORA, Tzaiwen CHIU, Petr LÁNSKÝ a Paul Waifung POON. Altered intensity coding in the salicylate-overdose animal model of tinnitus. \textit{BioSystems}. ELSEVIER SCI LTD, 2015, roč.~136, october, s.~113-119. ISSN~0303-2647. Dostupné z: https://dx.doi.org/10.1016/j.biosystems.2015.06.010.

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