| ĎURČ, Pavol, Michal GREGUŠ, Júlia LAČNÁ, Eva POKOJOVÁ, Jana SKŘIČKOVÁ, František FORET a Petr KUBÁŇ. NON-INVASIVE SAMPLING AND SUBSEQUENT CAPILLARY ELECTROPHORETIC ANALYSIS OF SWEAT AND SALIVA IN CLINICAL DIAGNOSIS OF CYSTIC FIBROSIS. In Foret, F Krenkova, J Drobnikova, I Guttman, A Kleparnik, K. CECE 2014: 11TH INTERNATIONAL INTERDISCIPLINARY MEETING ON BIOANALYSIS. BRNO: INST ANALYTICAL CHEMISTRY ASCR, V V I-IAC, 2014, s. 182-186. ISBN 978-80-904959-2-0. |
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@inproceedings{1306294,
author = {Ďurč, Pavol and Greguš, Michal and Lačná, Júlia and Pokojová, Eva and Skřičková, Jana and Foret, František and Kubáň, Petr},
address = {BRNO},
booktitle = {CECE 2014: 11TH INTERNATIONAL INTERDISCIPLINARY MEETING ON BIOANALYSIS},
editor = {Foret, F Krenkova, J Drobnikova, I Guttman, A Kleparnik, K},
keywords = {Capillary electrophoresis},
howpublished = {tištěná verze "print"},
language = {eng},
location = {BRNO},
isbn = {978-80-904959-2-0},
pages = {182-186},
publisher = {INST ANALYTICAL CHEMISTRY ASCR, V V I-IAC},
title = {NON-INVASIVE SAMPLING AND SUBSEQUENT CAPILLARY ELECTROPHORETIC ANALYSIS OF SWEAT AND SALIVA IN CLINICAL DIAGNOSIS OF CYSTIC FIBROSIS},
year = {2014}
}
TY - JOUR
ID - 1306294
AU - Ďurč, Pavol - Greguš, Michal - Lačná, Júlia - Pokojová, Eva - Skřičková, Jana - Foret, František - Kubáň, Petr
PY - 2014
TI - NON-INVASIVE SAMPLING AND SUBSEQUENT CAPILLARY ELECTROPHORETIC ANALYSIS OF SWEAT AND SALIVA IN CLINICAL DIAGNOSIS OF CYSTIC FIBROSIS
PB - INST ANALYTICAL CHEMISTRY ASCR, V V I-IAC
CY - BRNO
SN - 9788090495920
KW - Capillary electrophoresis
N2 - Capillary electrophoresis (CE) with double opposite end injection (DOEI) and contactless conductivity detection (C4D) was used in a novel approach for diagnosis of cystic fibrosis (CF). A simple, fast and inexpensive "skin wipe" technique for sweat sampling was developed as a time-saving substitute for conventional, iontophoretic sweat sampling. Saliva sample was also obtained. A number of major target analytes (inorganic/organic anions and inorganic cations) were quantified simultaneously in these samples. By applying principal component analysis (PCA) to ion concentration ratios, rather than to individual ion concentrations, more accurate diagnostic tool for CF was obtained. We demonstrate that by using the developed approach and comparing a group of healthy individuals to patients diagnosed with CF, two clearly distinguished clusters can be observed without any data overlap. This approach may thus set a basis for a new method to diagnose CF more reliably.
ER -
ĎURČ, Pavol, Michal GREGUŠ, Júlia LAČNÁ, Eva POKOJOVÁ, Jana SKŘIČKOVÁ, František FORET a Petr KUBÁŇ. NON-INVASIVE SAMPLING AND SUBSEQUENT CAPILLARY ELECTROPHORETIC ANALYSIS OF SWEAT AND SALIVA IN CLINICAL DIAGNOSIS OF CYSTIC FIBROSIS. In Foret, F Krenkova, J Drobnikova, I Guttman, A Kleparnik, K. \textit{CECE 2014: 11TH INTERNATIONAL INTERDISCIPLINARY MEETING ON BIOANALYSIS}. BRNO: INST ANALYTICAL CHEMISTRY ASCR, V V I-IAC, 2014, s.~182-186. ISBN~978-80-904959-2-0.
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