Fate of the Molar Dental Lamina in the Monophyodont Mouse

J 2015

Fate of the Molar Dental Lamina in the Monophyodont Mouse

DOSEDĚLOVÁ, Hana, Jana DUMKOVÁ, Hervé LESOT, Kristýna GLOCOVÁ, Michaela KUNOVÁ et. al.

Základní údaje

Originální název

Fate of the Molar Dental Lamina in the Monophyodont Mouse

Autoři

DOSEDĚLOVÁ, Hana (203 Česká republika), Jana DUMKOVÁ (203 Česká republika, domácí), Hervé LESOT (250 Francie), Kristýna GLOCOVÁ (203 Česká republika), Michaela KUNOVÁ (203 Česká republika, domácí), Abigail S. TUCKER (826 Velká Británie a Severní Irsko), Iva VESELÁ (203 Česká republika), Pavel KREJČÍ (203 Česká republika, domácí), František TICHÝ (203 Česká republika), Aleš HAMPL (203 Česká republika, domácí) a marcela BUCHTOVÁ (203 Česká republika, garant, domácí)

Vydání

Plos one, San Francisco, Public Library Science, 2015, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.057

Kód RIV

RIV/00216224:14310/15:00094512

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1371/journal.pone.0127543

UT WoS

000355183900107

Klíčová slova anglicky

EPITHELIAL STEM-CELLS; TOOTH REPLACEMENT; ODONTOBLAST DIFFERENTIATION; BASAL LAMINA; TEETH; PROLIFERATION; HEDGEHOG; MORPHOGENESIS; DENTITION; SOX2

Štítky

EL OK, NZ, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 13. 4. 2018 15:29, Ing. Nicole Zrilić

Anotace

V originále

The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

Citovat

DOSEDĚLOVÁ, Hana, Jana DUMKOVÁ, Hervé LESOT, Kristýna GLOCOVÁ, Michaela KUNOVÁ, Abigail S. TUCKER, Iva VESELÁ, Pavel KREJČÍ, František TICHÝ, Aleš HAMPL a marcela BUCHTOVÁ. Fate of the Molar Dental Lamina in the Monophyodont Mouse. Plos one. San Francisco: Public Library Science, 2015, roč. 10, č. 5, s. nestránkováno, 22 s. ISSN 1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0127543.

@article{1306866,
   author = {Dosedělová, Hana and Dumková, Jana and Lesot, Hervé and Glocová, Kristýna and Kunová, Michaela and Tucker, Abigail S. and Veselá, Iva and Krejčí, Pavel and Tichý, František and Hampl, Aleš and Buchtová, marcela},
   article_location = {San Francisco},
   article_number = {5},
   doi = {http://dx.doi.org/10.1371/journal.pone.0127543},
   keywords = {EPITHELIAL STEM-CELLS; TOOTH REPLACEMENT; ODONTOBLAST DIFFERENTIATION; BASAL LAMINA; TEETH; PROLIFERATION; HEDGEHOG; MORPHOGENESIS; DENTITION; SOX2},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Fate of the Molar Dental Lamina in the Monophyodont Mouse},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1306866
AU  - Dosedělová, Hana - Dumková, Jana - Lesot, Hervé - Glocová, Kristýna - Kunová, Michaela - Tucker, Abigail S. - Veselá, Iva - Krejčí, Pavel - Tichý, František - Hampl, Aleš - Buchtová, marcela
PY  - 2015
TI  - Fate of the Molar Dental Lamina in the Monophyodont Mouse
JF  - Plos one
VL  - 10
IS  - 5
SP  - nestránkováno
EP  - nestránkováno
PB  - Public Library Science
SN  - 19326203
KW  - EPITHELIAL STEM-CELLS
KW  - TOOTH REPLACEMENT
KW  - ODONTOBLAST DIFFERENTIATION
KW  - BASAL LAMINA
KW  - TEETH
KW  - PROLIFERATION
KW  - HEDGEHOG
KW  - MORPHOGENESIS
KW  - DENTITION
KW  - SOX2
N2  - The successional dental lamina (SDL) plays an essential role in the development of replacement teeth in diphyodont and polyphyodont animals. A morphologically similar structure, the rudimental successional dental lamina (RSDL), has been described in monophyodont (only one tooth generation) lizards on the lingual side of the developing functional tooth. This rudimentary lamina regresses, which has been proposed to play a role in preventing the formation of future generations of teeth. A similar rudimentary lingual structure has been reported associated with the first molar in the monophyodont mouse, and we show that this structure is common to all murine molars. Intriguingly, a lingual lamina is also observed on the non-replacing molars of other diphyodont mammals (pig and hedgehog), initially appearing very similar to the successional dental lamina on the replacing teeth. We have analyzed the morphological as well as ultrastructural changes that occur during the development and loss of this molar lamina in the mouse, from its initiation at late embryonic stages to its disappearance at postnatal stages. We show that loss appears to be driven by a reduction in cell proliferation, down-regulation of the progenitor marker Sox2, with only a small number of cells undergoing programmed cell death. The lingual lamina was associated with the dental stalk, a short epithelial connection between the tooth germ and the oral epithelium. The dental stalk remained in contact with the oral epithelium throughout tooth development up to eruption when connective tissue and numerous capillaries progressively invaded the dental stalk. The buccal side of the dental stalk underwent keratinisation and became part of the gingival epithelium, while most of the lingual cells underwent programmed cell death and the tissue directly above the erupting tooth was shed into the oral cavity.
ER  -

DOSEDĚLOVÁ, Hana, Jana DUMKOVÁ, Hervé LESOT, Kristýna GLOCOVÁ, Michaela KUNOVÁ, Abigail S. TUCKER, Iva VESELÁ, Pavel KREJČÍ, František TICHÝ, Aleš HAMPL a marcela BUCHTOVÁ. Fate of the Molar Dental Lamina in the Monophyodont Mouse. \textit{Plos one}. San Francisco: Public Library Science, 2015, roč.~10, č.~5, s.~nestránkováno, 22 s. ISSN~1932-6203. Dostupné z: https://dx.doi.org/10.1371/journal.pone.0127543.

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