a 2015

Haplotype analysis of interleukin-6 gene promoter polymorphisms in patients with chronic periodontitis and diabetes mellitus

VALOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Kateřina KAŇKOVÁ, Hana POSKEROVÁ, Jan VOKURKA et. al.

Basic information

Original name

Haplotype analysis of interleukin-6 gene promoter polymorphisms in patients with chronic periodontitis and diabetes mellitus

Name in Czech

Analýza haplotypů polymorfizmů v promotoru genu pro interleukin-6 u pacientů s chronickou parodontitidou a diabetem mellitem

Authors

VALOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution), Hana POSKEROVÁ (203 Czech Republic), Jan VOKURKA (203 Czech Republic), Antonín FASSMANN (203 Czech Republic) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution)

Edition

The 12th World Congress on Inflammation, 2015

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.557

RIV identification code

RIV/00216224:14110/15:00080957

Organization unit

Faculty of Medicine

ISSN

DOI

Keywords in English

IL-6; polymorphism; chronic periodontitis; diabetes mellitus; haplotype

Tags

Změněno: 27/1/2016 14:38, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

The aim of our study was to investigate the association of single nucleotide polymorphisms at positions -174G/C (rs1800795), -572G/C (rs1800796) and -597G/A (rs1800797), and their combinations (haplotypes) in patients with CP, type 1 DM (T1DM) and type 2 DM (T2DM) in comparison with healthy controls. Our results indicate that different IL-6 promoter haplotypes can affect the risk for CP and DM development. However, the individual IL-6 gene promoter polymorphisms do not act independently and may affect each other.

Links

GB14-37368G, research and development project
Name: Centrum orofaciálního vývoje a regenerace
Investor: Czech Science Foundation
MUNI/A/1359/2014, interní kód MU
Name: Etiopatogeneze, diagnostika a léčba vybraných patologických stavů v dutině ústní
Investor: Masaryk University, Category A
NT11405, research and development project
Name: Mikrobiologické a genetické determinanty rozvoje a progrese parodontitidy u diabetiků 1. a 2. typu a jejich reciproční vztah ke kompenzaci diabetu
Investor: Ministry of Health of the CR