| ERDEM, Hakan, Yasemin CAG, Derya OZTURK-ENGIN, Sylviane DEFRES, Selcuk KAYA, Lykke LARSEN, Mario POLJAK, Bruno BARSIC, Xavier ARGEMI, Signe Maj SØRENSEN, Anne Lisbeth BOHR, Pierre TATTEVIN, Jesper Damsgaard GUNST, Lenka BAŠTÁKOVÁ, Matjaž JEREB, Isik Somuncu JOHANSEN, Oguz KARABAY, Abdullah Umut PEKOK, Oguz Resat SIPAHI, Mahtab CHEHRI, Guillaume BERAUD, Ghaydaa SHEHATA, Rosa Fontana DEL VECCHIO, Mauro MARESCA, Hasan KARSEN, Gonul SENGOZ, Mustafa SUNBUL, Gulden YILMAZ, Hava YILMAZ, Ahmad SHARIF-YAKAN, Souha Shararah KANJ, Emine PARLAK, Filiz PEHLIVANOGLU, Fatime KORKMAZ, Suheyla KOMUR, Sukran KOSE, Mehmet ULUG, Sibel BOLUKCU, Seher Ayten COSKUNER, Nevin INCE, Yasemin AKKOYUNLU, Gulistan HALAC, Elif SAHIN-HORASAN, Hulya TIRELI, Gamze KILICOGLU, Akram AL-MANDAWI, Salih Atakan NEMLI, Asuman INAN, Seniha SENBAYRAK, Jean Paul STAHL a Haluk VAHABOGLU. Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis. Antimicrobial Agents and Chemotherapy. Washington: American Society for Microbiology, 2015, roč. 59, č. 6, s. 3084-3089. ISSN 0066-4804. Dostupné z: https://dx.doi.org/10.1128/AAC.05016-14. |
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@article{1309295,
author = {Erdem, Hakan and Cag, Yasemin and OzturkandEngin, Derya and Defres, Sylviane and Kaya, Selcuk and Larsen, Lykke and Poljak, Mario and Barsic, Bruno and Argemi, Xavier and Sørensen, Signe Maj and Bohr, Anne Lisbeth and Tattevin, Pierre and Gunst, Jesper Damsgaard and Baštáková, Lenka and Jereb, Matjaž and Johansen, Isik Somuncu and Karabay, Oguz and Pekok, Abdullah Umut and Sipahi, Oguz Resat and Chehri, Mahtab and Beraud, Guillaume and Shehata, Ghaydaa and Del Vecchio, Rosa Fontana and Maresca, Mauro and Karsen, Hasan and Sengoz, Gonul and Sunbul, Mustafa and Yilmaz, Gulden and Yilmaz, Hava and SharifandYakan, Ahmad and Kanj, Souha Shararah and Parlak, Emine and Pehlivanoglu, Filiz and Korkmaz, Fatime and Komur, Suheyla and Kose, Sukran and Ulug, Mehmet and Bolukcu, Sibel and Coskuner, Seher Ayten and Ince, Nevin and Akkoyunlu, Yasemin and Halac, Gulistan and SahinandHorasan, Elif and Tireli, Hulya and Kilicoglu, Gamze and AlandMandawi, Akram and Nemli, Salih Atakan and Inan, Asuman and Senbayrak, Seniha and Stahl, Jean Paul and Vahaboglu, Haluk},
article_location = {Washington},
article_number = {6},
doi = {http://dx.doi.org/10.1128/AAC.05016-14},
keywords = {CENTRAL-NERVOUS-SYSTEM; SIMPLEX ENCEPHALITIS; BACTERIAL-MENINGITIS; PRACTICE GUIDELINES; ADULT PATIENTS; ACYCLOVIR; MANAGEMENT; INFECTIONS; MANIFESTATIONS; MULTICENTER},
language = {eng},
issn = {0066-4804},
journal = {Antimicrobial Agents and Chemotherapy},
title = {Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis},
volume = {59},
year = {2015}
}
TY - JOUR
ID - 1309295
AU - Erdem, Hakan - Cag, Yasemin - Ozturk-Engin, Derya - Defres, Sylviane - Kaya, Selcuk - Larsen, Lykke - Poljak, Mario - Barsic, Bruno - Argemi, Xavier - Sørensen, Signe Maj - Bohr, Anne Lisbeth - Tattevin, Pierre - Gunst, Jesper Damsgaard - Baštáková, Lenka - Jereb, Matjaž - Johansen, Isik Somuncu - Karabay, Oguz - Pekok, Abdullah Umut - Sipahi, Oguz Resat - Chehri, Mahtab - Beraud, Guillaume - Shehata, Ghaydaa - Del Vecchio, Rosa Fontana - Maresca, Mauro - Karsen, Hasan - Sengoz, Gonul - Sunbul, Mustafa - Yilmaz, Gulden - Yilmaz, Hava - Sharif-Yakan, Ahmad - Kanj, Souha Shararah - Parlak, Emine - Pehlivanoglu, Filiz - Korkmaz, Fatime - Komur, Suheyla - Kose, Sukran - Ulug, Mehmet - Bolukcu, Sibel - Coskuner, Seher Ayten - Ince, Nevin - Akkoyunlu, Yasemin - Halac, Gulistan - Sahin-Horasan, Elif - Tireli, Hulya - Kilicoglu, Gamze - Al-Mandawi, Akram - Nemli, Salih Atakan - Inan, Asuman - Senbayrak, Seniha - Stahl, Jean Paul - Vahaboglu, Haluk
PY - 2015
TI - Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis
JF - Antimicrobial Agents and Chemotherapy
VL - 59
IS - 6
SP - 3084-3089
EP - 3084-3089
PB - American Society for Microbiology
SN - 00664804
KW - CENTRAL-NERVOUS-SYSTEM
KW - SIMPLEX ENCEPHALITIS
KW - BACTERIAL-MENINGITIS
KW - PRACTICE GUIDELINES
KW - ADULT PATIENTS
KW - ACYCLOVIR
KW - MANAGEMENT
KW - INFECTIONS
KW - MANIFESTATIONS
KW - MULTICENTER
N2 - Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
ER -
ERDEM, Hakan, Yasemin CAG, Derya OZTURK-ENGIN, Sylviane DEFRES, Selcuk KAYA, Lykke LARSEN, Mario POLJAK, Bruno BARSIC, Xavier ARGEMI, Signe Maj SØRENSEN, Anne Lisbeth BOHR, Pierre TATTEVIN, Jesper Damsgaard GUNST, Lenka BAŠTÁKOVÁ, Matjaž JEREB, Isik Somuncu JOHANSEN, Oguz KARABAY, Abdullah Umut PEKOK, Oguz Resat SIPAHI, Mahtab CHEHRI, Guillaume BERAUD, Ghaydaa SHEHATA, Rosa Fontana DEL VECCHIO, Mauro MARESCA, Hasan KARSEN, Gonul SENGOZ, Mustafa SUNBUL, Gulden YILMAZ, Hava YILMAZ, Ahmad SHARIF-YAKAN, Souha Shararah KANJ, Emine PARLAK, Filiz PEHLIVANOGLU, Fatime KORKMAZ, Suheyla KOMUR, Sukran KOSE, Mehmet ULUG, Sibel BOLUKCU, Seher Ayten COSKUNER, Nevin INCE, Yasemin AKKOYUNLU, Gulistan HALAC, Elif SAHIN-HORASAN, Hulya TIRELI, Gamze KILICOGLU, Akram AL-MANDAWI, Salih Atakan NEMLI, Asuman INAN, Seniha SENBAYRAK, Jean Paul STAHL a Haluk VAHABOGLU. Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis. \textit{Antimicrobial Agents and Chemotherapy}. Washington: American Society for Microbiology, 2015, roč.~59, č.~6, s.~3084-3089. ISSN~0066-4804. Dostupné z: https://dx.doi.org/10.1128/AAC.05016-14.
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