J 2015

Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?

ŠMAJS, David, Lenka PAŠTĚKOVÁ and Linda GRILLOVÁ

Basic information

Original name

Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains?

Authors

ŠMAJS, David (203 Czech Republic, guarantor, belonging to the institution), Lenka PAŠTĚKOVÁ (203 Czech Republic, belonging to the institution) and Linda GRILLOVÁ (203 Czech Republic, belonging to the institution)

Edition

American Journal of Tropical Medicine and Hygiene, McLean, American Society of Tropical Medicine and Hygiene, 2015, 0002-9637

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30300 3.3 Health sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.453

RIV identification code

RIV/00216224:14110/15:00081041

Organization unit

Faculty of Medicine

DOI

UT WoS

000362311800003

Keywords in English

SINGLE-DOSE AZITHROMYCIN; COMPLETE GENOME SEQUENCE; RIBOSOMAL-RNA GENES; HUMAN-IMMUNODEFICIENCY-VIRUS; PENICILLIN-BINDING PROTEIN; TIME MULTIPLEX PCR; SECONDARY SYPHILIS; TREATMENT FAILURE; POINT MUTATION; ERYTHROMYCIN RESISTANCE

Tags

Tags

International impact, Reviewed
Změněno: 5/1/2016 13:42, Ing. Mgr. Věra Pospíšilíková

Abstract

V originále

Treponema pallidum ssp. pallidum (TPA) causes over 10 million new cases of syphilis worldwide whereas T. pallidum ssp. pertenue (TPE), the causative agent of yaws, affects about 2.5 million people. Although penicillin remains the drug of choice in the treatment of syphilis, in penicillin-allergic patients, macrolides have been used in this indication since the 1950s. Failures of macrolides in syphilis treatment have been well documented in the literature and since 2000, there has been a dramatic increase in a number of clinical samples with macrolide-resistant TPA. Scarce data regarding the genetics of macrolide-resistant mutations in TPA suggest that although macrolideresistance mutations have emerged independently several times, the increase in the proportion of TPA strains resistant to macrolides is mainly due to the spread of resistant strains, especially in developed countries. The emergence of macrolide resistance in TPA appears to require a two-step process including either A2058G or A2059G mutation in one copy of the 23S rRNA gene and a subsequent gene conversion unification of both rRNA genes. Given the enormous genetic similarity that was recently revealed between TPA and TPE strains, there is a low but reasonable risk of emergence and spread of macrolide-resistant yaws strains following azithromycin treatment.

Links

GAP302/12/0574, research and development project
Name: Celogenomové sekvencování v analýze genomů a transkriptomů patogenních bakterií rodu Treponema
Investor: Czech Science Foundation