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@article{1312067, author = {Kováčová, Silvia and Adla, Santosh Kumar and Maier, Lukáš and Babiak, Michal and Mizushina, Yoshiyuki and Paruch, Kamil}, article_number = {40}, doi = {http://dx.doi.org/10.1016/j.tet.2015.08.005}, keywords = {Dehydroaltenusin; DNA polymerase; DNA damage repair; Spirocyclic compounds; Regioselective aldol condensation}, language = {eng}, issn = {0040-4020}, journal = {Tetrahedron}, title = {Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase a}, volume = {71}, year = {2015} }
TY - JOUR ID - 1312067 AU - Kováčová, Silvia - Adla, Santosh Kumar - Maier, Lukáš - Babiak, Michal - Mizushina, Yoshiyuki - Paruch, Kamil PY - 2015 TI - Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase a JF - Tetrahedron VL - 71 IS - 40 SP - 7575-7582 EP - 7575-7582 PB - Pergamon Press SN - 00404020 KW - Dehydroaltenusin KW - DNA polymerase KW - DNA damage repair KW - Spirocyclic compounds KW - Regioselective aldol condensation N2 - Syntheses of carbocyclic analogs of dehydroaltenusin tautomers are reported. Both target compounds, cDHA (2,8-dihydroxy-6-methoxy-10a-methyl-10,10a-dihydrophenanthrene-3,9-dione) and cDHAs (4,5-dihydroxy-6-methoxy-2-methylspiro[cyclohexa[2,5]diene-1,1-indene]-3,4(2H)-dione), were prepared from 3,5-dimethoxybenzaldehyde in 11 and 13 steps, respectively. Unlike dehydroaltenusin, both cDHA and cDHAs are stable and their structures were confirmed by X-ray crystallography. Compound cDHA was found to be active against calf DNA polymerase a but not related isozymes, while the spirocyclic analog cDHAs was inactive. ER -
KOVÁČOVÁ, Silvia, Santosh Kumar ADLA, Lukáš MAIER, Michal BABIAK, Yoshiyuki MIZUSHINA a Kamil PARUCH. Synthesis of carbocyclic analogs of dehydroaltenusin: identification of a stable inhibitor of calf DNA polymerase a. \textit{Tetrahedron}. Pergamon Press, 2015, roč.~71, č.~40, s.~7575-7582. ISSN~0040-4020. Dostupné z: https://dx.doi.org/10.1016/j.tet.2015.08.005.
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