Assessment of severity and progression of canine cognitive
dysfunction syndrome using the CAnine DEmentia Scale (CADES)

J 2015

Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)

MAĎARI, Aladár, Jana FARBAKOVÁ, Stanislav KATINA, Tomas SMOLEK, Petr NOVAK et. al.

Základní údaje

Originální název

Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)

Autoři

MAĎARI, Aladár (703 Slovensko), Jana FARBAKOVÁ (703 Slovensko), Stanislav KATINA (703 Slovensko, garant, domácí), Tomas SMOLEK (703 Slovensko), Petr NOVAK (703 Slovensko), Tatiana WEISSOVA (703 Slovensko), Michal NOVAK (703 Slovensko) a Norbert ZILKA (703 Slovensko)

Vydání

Applem Animal Behaviour Science, Elsevier, 2015, 0168-1591

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10103 Statistics and probability

Stát vydavatele

Nizozemské království

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL URL

Impakt faktor

Impact factor: 1.795

Kód RIV

RIV/00216224:14310/15:00084031

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.applanim.2015.08.034

UT WoS

000364605200018

Klíčová slova anglicky

Canine cognitive dysfunction syndrome; Canine dementia; Mild cognitive impairment; Annual conversion rate; Staging

Štítky

AKR, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 10. 2018 09:50, doc. PaedDr. RNDr. Stanislav Katina, Ph.D.

Anotace

V originále

Cognitive dysfunction syndrome (CDS) represents a group of symptoms related to the aging of the canine brain. These changes ultimately lead to a decline of memory function and learning abilities, alteration of social interaction, impairment of normal housetraining, changes in sleep–wake cycle and general activity. The initial symptoms gradually worsen over time. Despite extensive research, little is known about the staging and phenotypic variability of CDS. We have analysed more than 300 dogs; 215 were selected for the study. We developed a rating scale, CADES – canine dementia scale – containing 17 items distributed into four domains, related to changes in dogs’ behaviour: spatial orientation, social interactions, sleep–wake cycles and house soiling. Using CADES, we identified various stages of cognitive impairment: mild cognitive impairment, moderate cognitive impairment and severe cognitive dysfunction. Further, we found that the rate of conversion at 6-months follow-up of normal ageing to mild cognitive impairment was 42%, while conversion rate of mild to moderate cognitive impairment was 24%. At twelve months, the conversion rates almost doubled to 71.45% and 50%, respectively. These findings showed that CADES can be used as a predictor of conversion from normal ageing to mild, and from mild to moderate cognitive impairment. In regards to the four behavioural domains we found that impairment in social interaction was frequently present in dogs with mild cognitive impairment (40%), 67% of dogs with moderate cognitive impairment had affected social interaction and sleep–wake cycles. For severe cognitive dysfunction, the majority of dogs displayed impairment in all four domains, while other two subgroups showed impairment only in three domains. In this study, we have assessed the psychometric properties of the CADES scale, and validated it as a screening tool for CDS. The scale is also suitable for long-term assessment of the progression of cognitive impairment in canines, and potentially as efficacy readout for treatments.

Citovat

MAĎARI, Aladár, Jana FARBAKOVÁ, Stanislav KATINA, Tomas SMOLEK, Petr NOVAK, Tatiana WEISSOVA, Michal NOVAK a Norbert ZILKA. Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES). Applem Animal Behaviour Science. Elsevier, 2015, roč. 171, OCTOBER, s. 138-145. ISSN 0168-1591. Dostupné z: https://dx.doi.org/10.1016/j.applanim.2015.08.034.

@article{1312431,
   author = {Maďari, Aladár and Farbaková, Jana and Katina, Stanislav and Smolek, Tomas and Novak, Petr and Weissova, Tatiana and Novak, Michal and Zilka, Norbert},
   article_number = {OCTOBER},
   doi = {http://dx.doi.org/10.1016/j.applanim.2015.08.034},
   keywords = {Canine cognitive dysfunction syndrome; Canine dementia; Mild cognitive impairment; Annual conversion rate; Staging},
   language = {eng},
   issn = {0168-1591},
   journal = {Applem Animal Behaviour Science},
   title = {Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)},
   url = {http://www.sciencedirect.com/science/article/pii/S0168159115002373},
   volume = {171},
   year = {2015}
}

TY  - JOUR
ID  - 1312431
AU  - Maďari, Aladár - Farbaková, Jana - Katina, Stanislav - Smolek, Tomas - Novak, Petr - Weissova, Tatiana - Novak, Michal - Zilka, Norbert
PY  - 2015
TI  - Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES)
JF  - Applem Animal Behaviour Science
VL  - 171
IS  - OCTOBER
SP  - 138-145
EP  - 138-145
PB  - Elsevier
SN  - 01681591
KW  - Canine cognitive dysfunction syndrome
KW  - Canine dementia
KW  - Mild cognitive impairment
KW  - Annual conversion rate
KW  - Staging
UR  - http://www.sciencedirect.com/science/article/pii/S0168159115002373
L2  - http://www.sciencedirect.com/science/article/pii/S0168159115002373
N2  - Cognitive dysfunction syndrome (CDS) represents a group of symptoms related to the aging of the canine brain. These changes ultimately lead to a decline of memory function and learning abilities, alteration of social interaction, impairment of normal housetraining, changes in sleep–wake cycle and general activity. The initial symptoms gradually worsen over time. Despite extensive research, little is known about the staging and phenotypic variability of CDS. We have analysed more than 300 dogs; 215 were selected for the study. We developed a rating scale, CADES – canine dementia scale – containing 17 items distributed into four domains, related to changes in dogs’ behaviour: spatial orientation, social interactions, sleep–wake cycles and house soiling. Using CADES, we identified various stages of cognitive impairment: mild cognitive impairment, moderate cognitive impairment and severe cognitive dysfunction. Further, we found that the rate of conversion at 6-months follow-up of normal ageing to mild cognitive impairment was 42%, while conversion rate of mild to moderate cognitive impairment was 24%. At twelve months, the conversion rates almost doubled to 71.45% and 50%, respectively. These findings showed that CADES can be used as a predictor of conversion from normal ageing to mild, and from mild to moderate cognitive impairment. In regards to the four behavioural domains we found that impairment in social interaction was frequently present in dogs with mild cognitive impairment (40%), 67% of dogs with moderate cognitive impairment had affected social interaction and sleep–wake cycles. For severe cognitive dysfunction, the majority of dogs displayed impairment in all four domains, while other two subgroups showed impairment only in three domains. In this study, we have assessed the psychometric properties of the CADES scale, and validated it as a screening tool for CDS. The scale is also suitable for long-term assessment of the progression of cognitive impairment in canines, and potentially as efficacy readout for treatments.
ER  -

MAĎARI, Aladár, Jana FARBAKOVÁ, Stanislav KATINA, Tomas SMOLEK, Petr NOVAK, Tatiana WEISSOVA, Michal NOVAK a Norbert ZILKA. Assessment of severity and progression of canine cognitive dysfunction syndrome using the CAnine DEmentia Scale (CADES). \textit{Applem Animal Behaviour Science}. Elsevier, 2015, roč.~171, OCTOBER, s.~138-145. ISSN~0168-1591. Dostupné z: https://dx.doi.org/10.1016/j.applanim.2015.08.034.

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