Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1313241,
author = {Pleskačová, Anna and Pácal, Lukáš and Kuricová, Katarína and Kaňková, Kateřina},
booktitle = {12th International Symposium on the Maillard Reaction},
keywords = {RAGE, DNA methylation, hyperglycemia},
title = {RAGE PROMOTER METHYLATION IN VITRO AND IN VIVO},
year = {2015}
}
TY - CONF
ID - 1313241
AU - Pleskačová, Anna - Pácal, Lukáš - Kuricová, Katarína - Kaňková, Kateřina
PY - 2015
TI - RAGE PROMOTER METHYLATION IN VITRO AND IN VIVO
KW - RAGE, DNA methylation, hyperglycemia
N2 - Sustained over-activation of the Receptor for Advanced Glycation End-products (RAGE) in diabetes is considered one of the pathways involved in hyperglycemia induced damage and chronic inflammation. One of the possible explanations might be epigenetic changes induced by high glucose, which were described to be responsible for the “metabolic memory” phenomenon. The aim of this study was to determine RAGE promoter methylation in cytosin-guanine dinucleotides (CpGs) in vitro in endothelial (HUVEC) and embryonic kidney (HEK-293) cell lines in hyper- vs. normoglycemic conditions and in vivo (peripheral blood cells, PBCs) in patients with T2DM with established diabetic kidney disease (DKD, n = 12) compared to healthy counterparts (n = 12) .
ER -
PLESKAČOVÁ, Anna, Lukáš PÁCAL, Katarína KURICOVÁ a Kateřina KAŇKOVÁ. RAGE PROMOTER METHYLATION IN VITRO AND IN VIVO. In \textit{12th International Symposium on the Maillard Reaction}. 2015.
|
