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@proceedings{1313751,
author = {Škorpíková, Lucie and Koudela, Břetislav and Ilgová, Jana and Gelnar, Milan and Kašný, Martin},
booktitle = {22nd HELMINTHOLOGICAL DAYS},
keywords = {Trichinella sp.; cystatin; excretory-secretory products},
language = {eng},
title = {Molecular characterization of cystatins of Trichinella spp.},
year = {2015}
}
TY - CONF
ID - 1313751
AU - Škorpíková, Lucie - Koudela, Břetislav - Ilgová, Jana - Gelnar, Milan - Kašný, Martin
PY - 2015
TI - Molecular characterization of cystatins of Trichinella spp.
KW - Trichinella sp.
KW - cystatin
KW - excretory-secretory products
N2 - Nematodes of the genus Trichinella are intracellular parasites which invade the cells of small intestine and skeletal muscles. Their global distribution is corresponding to the wide range of their hosts involving mammals, birds and reptiles. Six (T1, T2, T3, T4, T5 and T7) of twelve genotypes (T1-T12) of Trichinella are causative agents of human trichinellosis, a serious disease which has been documented in 55 countries. Our work is focused on cystatins - inhibitors of C1 cysteine peptidases. Their ancestor gene have undergone a complex and dynamic evolution implicating the current high variability of the cystatin group. Despite this fact, three amino acid conserved motifs of cystatin active site remain preserved. Cystatins are involved in many essential biological processes of helminths, including Trichinella spp., like development, growth, migration, digestion, reproduction and also in manipulation of the host immunne system. The presence of some cystatins was confirmed in excretory-secretory products of Trichinella muscle larvae and “multi cystatin-like domain” protein was recognized as a one of the most dominant components.
ER -
ŠKORPÍKOVÁ, Lucie, Břetislav KOUDELA, Jana ILGOVÁ, Milan GELNAR and Martin KAŠNÝ. Molecular characterization of cystatins of Trichinella spp. In \textit{22nd HELMINTHOLOGICAL DAYS}. 2015.
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