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@proceedings{1314400,
author = {Hyršl, Pavel and Dobeš, Pavel and Arefin, Badrul and Berka, Jakub and Kučerová, Lucie and Markus, Robert and Wang, Zhi and Žurovec, Michal and Theopold, Ulrich},
booktitle = {Workshop: Molecular methods in insect physiology},
keywords = {insect; Drosophila; immunity},
language = {eng},
title = {Immune response to nematobacterial infection},
year = {2015}
}
TY - CONF
ID - 1314400
AU - Hyršl, Pavel - Dobeš, Pavel - Arefin, Badrul - Berka, Jakub - Kučerová, Lucie - Markus, Robert - Wang, Zhi - Žurovec, Michal - Theopold, Ulrich
PY - 2015
TI - Immune response to nematobacterial infection
KW - insect
KW - Drosophila
KW - immunity
N2 - Entomopathogenic nematodes and their associated bacteria comprise together highly pathogenic complex able to invade and kill insect host within two days. Both bacteria and nematodes produce variety of factors interacting with insect immune system that help to overcome host defences. The tripartite model (Drosophila, nematodes, bacteria) was established and used to show an immune function for candidate genes using different Drosophila mutants or RNAi lines with defects in clotting or other branches of the immune system. We demonstrated an immune function during nematode infection for known clotting enzymes and substrates, recognition molecules, eicosanoids etc. In conclusion, we show that the Heterorhabditis/Photorhabdus infection model is suitable to identify novel regulators of innate immunity and we bring evidence of coagulation immune function in insects against nematode infection.
ER -
HYRŠL, Pavel, Pavel DOBEŠ, Badrul AREFIN, Jakub BERKA, Lucie KUČEROVÁ, Robert MARKUS, Zhi WANG, Michal ŽUROVEC a Ulrich THEOPOLD. Immune response to nematobacterial infection. In \textit{Workshop: Molecular methods in insect physiology}. 2015.
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