HOFFMANN, V.S., M. BACCARANI, J. HASFORD, D. LINDOERFER, S. BURGSTALLER, D. SERTIC, P. COSTEAS, Jiří MAYER, K. INDRAK, H. EVERAUS, P. KOSKENVESA, J. GUILHOT, G. SCHUBERT-FRITSCHLE, F. CASTAGNETTI, F. DI RAIMONDO, S. LEJNIECE, L. GRISKEVICIUS, N. THIELEN, T. SACHA, A. HELLMANN, A.G. TURKINA, A. ZARITSKEY, A. BOGDANOVICH, Z. SNINSKÁ, I. ZUPAN, J.L. STEEGMANN, B. SIMONSSON, R.E. CLARK, A. COVELLI, G. GUIDI and R. HEHLMANN. The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries. Leukemia. London: Nature Publishing Group, 2015, vol. 29, No 6, p. 1336-1343. ISSN 0887-6924. Available from: https://dx.doi.org/10.1038/leu.2015.73. |
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@article{1315211, author = {Hoffmann, V.S. and Baccarani, M. and Hasford, J. and Lindoerfer, D. and Burgstaller, S. and Sertic, D. and Costeas, P. and Mayer, Jiří and Indrak, K. and Everaus, H. and Koskenvesa, P. and Guilhot, J. and SchubertandFritschle, G. and Castagnetti, F. and Di Raimondo, F. and Lejniece, S. and Griskevicius, L. and Thielen, N. and Sacha, T. and Hellmann, A. and Turkina, A.G. and Zaritskey, A. and Bogdanovich, A. and Sninská, Z. and Zupan, I. and Steegmann, J.L. and Simonsson, B. and Clark, R.E. and Covelli, A. and Guidi, G. and Hehlmann, R.}, article_location = {London}, article_number = {6}, doi = {http://dx.doi.org/10.1038/leu.2015.73}, keywords = {CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; HEMATOLOGIC MALIGNANCIES; IMATINIB TREATMENT; INTERFERON-ALPHA; PROGNOSTIC SCORE; WORKING PARTY; FRONTLINE; SURVIVAL; THERAPY}, language = {eng}, issn = {0887-6924}, journal = {Leukemia}, title = {The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries}, volume = {29}, year = {2015} }
TY - JOUR ID - 1315211 AU - Hoffmann, V.S. - Baccarani, M. - Hasford, J. - Lindoerfer, D. - Burgstaller, S. - Sertic, D. - Costeas, P. - Mayer, Jiří - Indrak, K. - Everaus, H. - Koskenvesa, P. - Guilhot, J. - Schubert-Fritschle, G. - Castagnetti, F. - Di Raimondo, F. - Lejniece, S. - Griskevicius, L. - Thielen, N. - Sacha, T. - Hellmann, A. - Turkina, A.G. - Zaritskey, A. - Bogdanovich, A. - Sninská, Z. - Zupan, I. - Steegmann, J.L. - Simonsson, B. - Clark, R.E. - Covelli, A. - Guidi, G. - Hehlmann, R. PY - 2015 TI - The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries JF - Leukemia VL - 29 IS - 6 SP - 1336-1343 EP - 1336-1343 PB - Nature Publishing Group SN - 08876924 KW - CHRONIC MYELOID-LEUKEMIA KW - CHRONIC MYELOGENOUS LEUKEMIA KW - HEMATOLOGIC MALIGNANCIES KW - IMATINIB TREATMENT KW - INTERFERON-ALPHA KW - PROGNOSTIC SCORE KW - WORKING PARTY KW - FRONTLINE KW - SURVIVAL KW - THERAPY N2 - This population-based registry was designed to provide robust and updated information on the characteristics and the epidemiology of chronic myeloid leukemia (CML). All cases of newly diagnosed Philadelphia positive, BCR-ABL1+ CML that occurred in a sample of 92.5 million adults living in 20 European countries, were registered over a median period of 39 months. 94.3% of the 2904 CML patients were diagnosed in chronic phase (CP). Median age was 56 years. 55.5% of patients had comorbidities, mainly cardiovascular (41.9%). High-risk patients were 24.7% by Sokal, 10.8% by EURO, and 11.8% by EUTOS risk scores. The raw incidence increased with age from 0.39/100 000/year in people 20-29 years old to 1.52 in those >70 years old, and showed a maximum of 1.39 in Italy and a minimum of 0.69 in Poland (all countries together: 0.99). The proportion of Sokal and Euro score high-risk patients seen in many countries indicates that trial patients were not a positive selection. Thus from a clinical point of view the results of most trials can be generalized to most countries. The incidences observed among European countries did not differ substantially. The estimated number of new CML cases per year in Europe is about 6370. ER -
HOFFMANN, V.S., M. BACCARANI, J. HASFORD, D. LINDOERFER, S. BURGSTALLER, D. SERTIC, P. COSTEAS, Jiří MAYER, K. INDRAK, H. EVERAUS, P. KOSKENVESA, J. GUILHOT, G. SCHUBERT-FRITSCHLE, F. CASTAGNETTI, F. DI RAIMONDO, S. LEJNIECE, L. GRISKEVICIUS, N. THIELEN, T. SACHA, A. HELLMANN, A.G. TURKINA, A. ZARITSKEY, A. BOGDANOVICH, Z. SNINSKÁ, I. ZUPAN, J.L. STEEGMANN, B. SIMONSSON, R.E. CLARK, A. COVELLI, G. GUIDI and R. HEHLMANN. The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries. \textit{Leukemia}. London: Nature Publishing Group, 2015, vol.~29, No~6, p.~1336-1343. ISSN~0887-6924. Available from: https://dx.doi.org/10.1038/leu.2015.73.
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