Detailed Information on Publication Record
2016
The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature
VESELÝ, Branislav and Ivan REKTORBasic information
Original name
The contribution of white matter lesions (WML) to Parkinson's disease cognitive impairment symptoms: A critical review of the literature
Authors
VESELÝ, Branislav (703 Slovakia) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)
Edition
PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2016, 1353-8020
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.484
RIV identification code
RIV/00216224:14740/16:00089147
Organization unit
Central European Institute of Technology
UT WoS
000366781900036
Keywords in English
White matter lesions; Cerebrovascular disease; Parkinson's disease; Mild cognitive impairment; Dementia
Tags
Tags
International impact, Reviewed
Změněno: 31/8/2016 16:21, Mgr. Eva Špillingová
Abstract
V originále
We reviewed the impact of white matter lesions (WML) of cerebrovascular origin on cognitive impairment in Parkinson's disease (PD) patients. A search of PUBMED and Googlescholar.com revealed eleven studies that met the inclusion criteria: diagnosis based on the United Kingdom Brain Bank criteria (UK BBC); cognitive assessment; WML assessed on magnetic resonance imaging (MRI) by semiquantitative visual scales or automated method. Eight studies described the negative impact of WML on cognition in PD. Patients with mild cognitive impairment (MCI) and dementia had significantly more WML than the group without MCI and dementia. There was significant relationship between increasing total WML volume and worse performance on executive function, memory and language. Patients with vascular parkinsonism and dopaminergic denervation had more severe frontal lobe dysfunctions than patients with PD. In contrast in three studies there was no negative correlation between WML and cognition. Although the progression of neurodegenerative process in advanced stage of PD has been recognized as being mainly responsible for cognitive impairment in PD, WML may also be a contributing factor. It is possible that by reducing the vascular risk factors that cause WML cognitive impairment could be prevented or slowed down. (C) 2015 Elsevier Ltd. All rights reserved.
Links
ED1.1.00/02.0068, research and development project |
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