BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, roč. 64, č. 6, s. 939-943. ISSN 0862-8408. |
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@article{1315970, author = {Bébarová, Markéta and Matejovič, Peter and Šimurdová, Milena and Šimurda, Jiří}, article_location = {Praha}, article_number = {6}, keywords = {Acetaldehyde; Arrhythmias; Inward rectifier; IK1 inhibition; Rat ventricular myocytes}, language = {eng}, issn = {0862-8408}, journal = {Physiological Research}, title = {Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes}, volume = {64}, year = {2015} }
TY - JOUR ID - 1315970 AU - Bébarová, Markéta - Matejovič, Peter - Šimurdová, Milena - Šimurda, Jiří PY - 2015 TI - Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes JF - Physiological Research VL - 64 IS - 6 SP - 939-943 EP - 939-943 PB - Fyziologický ústav AV ČR SN - 08628408 KW - Acetaldehyde KW - Arrhythmias KW - Inward rectifier KW - IK1 inhibition KW - Rat ventricular myocytes N2 - Considering the effects of alcohol on cardiac electrical behaviour as well as the important role of the inward rectifier potassium current IK1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on IK1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of IK1 with IC50 = 53.7 +/- 7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1 +/- 3.0%). The inhibition was voltage-independent at physiological voltages above -90 mV. The IK1 changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2015, roč.~64, č.~6, s.~939-943. ISSN~0862-8408.
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