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@article{1316154,
author = {Kincl, Vladimír and Máchal, Jan and Drozdová, Adéla and Panovský, Roman and Vašků, Anna},
article_location = {New York},
article_number = {September},
doi = {http://dx.doi.org/10.1155/2015/232048},
keywords = {endothelial nitric oxide synthase; matrix metaloproteinase; eotaxin; gene polymorphism; coronary artery disease; survival},
language = {eng},
issn = {0278-0240},
journal = {Disease Markers},
title = {The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease},
url = {http://www.hindawi.com/journals/dm/2015/232048/},
volume = {2015},
year = {2015}
}
TY - JOUR
ID - 1316154
AU - Kincl, Vladimír - Máchal, Jan - Drozdová, Adéla - Panovský, Roman - Vašků, Anna
PY - 2015
TI - The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease
JF - Disease Markers
VL - 2015
IS - September
SP - 1-7
EP - 1-7
PB - Hindawi Publishing Corporation
SN - 02780240
KW - endothelial nitric oxide synthase
KW - matrix metaloproteinase
KW - eotaxin
KW - gene polymorphism
KW - coronary artery disease
KW - survival
UR - http://www.hindawi.com/journals/dm/2015/232048/
N2 - Aim. The purpose of this study is to determine the association between eotaxin 426 C/T, -384 A/G, 67 G/A, eNOS -786 T/C, 4 a/b, and MMP-13 rs640198 G/T and prognosis of patients with known CAD. Methods. From total of 1161 patients referred to coronary angiography, 532 patients with angiographically confirmed CAD were selected. Their long-term outcome was followed up using hospital database. Subsequent events were assessed in this study: death or combined endpoint-myocardial infarction, unstable angina pectoris, revascularization, heart failure hospitalization, and cardioverter-defibrillator implantation. Results. The multivariate Cox regression model identified age, smoking, and 3-vessel disease as significant predictors of all-cause death. Further analysis showed that eotaxin 67 G/A (GA + AA versus GG) and eotaxin -384 A/G (GG versus GA + AA) were significant independent prognostic factors when added into the model: HR (95% CI) 2.81 (1.35-5.85), p = 0.006; HR (95% CI) 2.63 (1.19-5.83), p = 0.017; eotaxin -384 A/G was significantly associated with the event-free survival, but it did not provide the prognostic information above the effect of two- or three-vessel disease. Conclusion. The A allele in eotaxin 67G/Apolymorphismis associated with worse survival in CAD patients.
ER -
KINCL, Vladimír, Jan MÁCHAL, Adéla DROZDOVÁ, Roman PANOVSKÝ a Anna VAŠKŮ. The Relation between eNOS-786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T,-384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. \textit{Disease Markers}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, September, s.~1-7. ISSN~0278-0240. Dostupné z: https://dx.doi.org/10.1155/2015/232048.
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