The possibilities of endoluminal ablation techniques

k 2015

The possibilities of endoluminal ablation techniques

ANDRAŠINA, Tomáš

Základní údaje

Originální název

The possibilities of endoluminal ablation techniques

Autoři

ANDRAŠINA, Tomáš (703 Slovensko, garant, domácí)

Vydání

27th International Conference of the Society for Medical Innovation and Technology, 2015

Další údaje

Jazyk

angličtina

Typ výsledku

Prezentace na konferencích

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/15:00087459

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

endoluminal techniques; ablation radiofrequency; irreversible electroporation; bile ducts

Štítky

EL OK

Změněno: 6. 4. 2016 14:35, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Tumours growing from the epithelium of the biliary tract are most common in the hilar region and the complexity of the perihilar liver region causes curative surgical resection to be very complicated. The resectability and the 5-year survival rate of hilar cholangiocarcinomas are very low. There are many tested chemotherapeutic regimes combining systemic delivery with intra-arterial chemotherapy or chemoembolization, but none of these has yet become the standard therapy. In addition to palliative surgical procedures, endoscopic and percutaneous therapeutic methods of the bile ducts drainage there are several competing techniques and interventions aiming to control of disease - radiation therapies (external beam, intraluminal brachytherapy), photodynamic therapies and endoluminal ablations. More often they are so-called tailored oncological therapies. Local ablation techniques such as endoluminal radiofrequency ablation with simple and one-time application are potentially useful in debulking of the endoluminal tumours, preventing early ingrowth of the tumours through the stent mesh, and even helping to resolve stent obstruction. Another alternative therapeutic intervention in this field is non-thermal ablation method - irreversible electroporation. During electroporation the cells in the tissue are exposed to the short pulses of very high voltages. Pulses of high voltage changes transmembrane electrochemical potential resulting in cell membrane instabilities and disruption of the membrane. The advantage of electroporation to the radiofrequency ablation is the absence of heat damage to healthy tissue, the precise shape and volume of necrosis and this technique also lacks of the heat sink effect. The architecture of the tissue is preserved and reparation along it is possible. Hilar cholangiocarcinoma is a complex medical problem. Survival times can be influenced by optimal drainage, brachytherapy, photodynamic therapy or other ablation treatments.

Návaznosti

NT14586, projekt VaV

Název: Choledochoskopem navigovaná radiofrekvenční ablace žlučových cest.

Investor: Ministerstvo zdravotnictví ČR, Choledochoskopem navigovaná radiofrekvenční ablace žlučových cest.

NV15-32484A, projekt VaV

Název: Využití nových biotechnologií v prevenci a léčbě stenóz žlučových cest

Citovat

ANDRAŠINA, Tomáš. The possibilities of endoluminal ablation techniques. In 27th International Conference of the Society for Medical Innovation and Technology. 2015.

@proceedings{1317068,
   author = {Andrašina, Tomáš},
   booktitle = {27th International Conference of the Society for Medical Innovation and Technology},
   keywords = {endoluminal techniques; ablation radiofrequency; irreversible electroporation; bile ducts},
   language = {eng},
   title = {The possibilities of endoluminal ablation techniques},
   year = {2015}
}

TY  - CONF
ID  - 1317068
AU  - Andrašina, Tomáš
PY  - 2015
TI  - The possibilities of endoluminal ablation techniques
KW  - endoluminal techniques
KW  - ablation radiofrequency
KW  - irreversible electroporation
KW  - bile ducts
N2  - Tumours growing from the epithelium of the biliary tract are most common in the hilar region and the complexity of the perihilar liver region causes curative surgical resection to be very complicated. The resectability and the 5-year survival rate of hilar cholangiocarcinomas are very low. There are many tested chemotherapeutic regimes combining systemic delivery with intra-arterial chemotherapy or chemoembolization, but none of these has yet become the standard therapy. In addition to palliative surgical procedures, endoscopic and percutaneous therapeutic methods of the bile ducts drainage there are several competing techniques and interventions aiming to control of disease - radiation therapies (external beam, intraluminal brachytherapy), photodynamic therapies and endoluminal ablations. More often they are so-called tailored oncological therapies. Local ablation techniques such as endoluminal radiofrequency ablation with simple and one-time application are potentially useful in debulking of the endoluminal tumours, preventing early ingrowth of the tumours through the stent mesh, and even helping to resolve stent obstruction. Another alternative therapeutic intervention in this field is non-thermal ablation method - irreversible electroporation. During electroporation the cells in the tissue are exposed to the short pulses of very high voltages. Pulses of high voltage changes transmembrane electrochemical potential resulting in cell membrane instabilities and disruption of the membrane. The advantage of electroporation to the radiofrequency ablation is the absence of heat damage to healthy tissue, the precise shape and volume of necrosis and this technique also lacks of the heat sink effect. The architecture of the tissue is preserved and reparation along it is possible. Hilar cholangiocarcinoma is a complex medical problem. Survival times can be influenced by optimal drainage, brachytherapy, photodynamic therapy or other ablation treatments.
ER  -

ANDRAŠINA, Tomáš. The possibilities of endoluminal ablation techniques. In \textit{27th International Conference of the Society for Medical Innovation and Technology}. 2015.

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