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@article{1317134, author = {Krajčovičová, Renáta and Hudeček, Robert and Ventruba, Pavel and Surgentová, Katarína}, article_location = {Larchmont}, article_number = {5}, doi = {http://dx.doi.org/10.1089/gyn.2014.0129}, keywords = {Asherman´s syndrome; menstrual cycle; hormonal therapy; hyaluronan}, language = {eng}, issn = {1042-4067}, journal = {Journal of gynecologic surgery}, title = {The Role of Hyaluronan in Asherman’s Syndrome Therapy}, volume = {31}, year = {2015} }
TY - JOUR ID - 1317134 AU - Krajčovičová, Renáta - Hudeček, Robert - Ventruba, Pavel - Surgentová, Katarína PY - 2015 TI - The Role of Hyaluronan in Asherman’s Syndrome Therapy JF - Journal of gynecologic surgery VL - 31 IS - 5 SP - 250-254 EP - 250-254 PB - Mary Ann Liebert Inc. SN - 10424067 KW - Asherman´s syndrome KW - menstrual cycle KW - hormonal therapy KW - hyaluronan N2 - Prospective clinical evaluation comparing the therapy of Asherman’s syndrome in patients treated using hysteroscopic (HSK) adhesiolysis with insertion of 100% hyaluronic acid (HA) to a patient cohort with an inserted intrauterine device (IUD) and a control cohort. Design: Primary outcome—treatment for menstrual cycle problems. Secondary outcome—attainment of pregnancy after spontaneous conception within 1 year after the ending of hormonal therapy. Materials and Methods: Sixty patients treated from 1997 to 2014 for Asherman’s syndrome (in Stage II and III). Cohort A: Insertion of 100% HA (20 patients). Cohort B: Insertion of an IUD (18 patients). Cohort C: Without insertion of antiadhesion agent (22 patients). Primary and secondary goals were evaluated for all patients after a 3-month hormonal therapy. Results: The normal menstrual cycle was restored in 12 out of 20 patients in cohort A (60.0%), in 10 out of 18 patients in cohort B (55.5%), and 8 out of 22 patients in control cohort C (36.3%). A spontaneous pregnancy within 1 year after the end of the treatment was achieved by 14 out of 18 patients (77.7%) in cohort A, by 6 out of 10 patients (60.0%) in cohort B, and by 6 out of 14 patients (42.8%) in cohort C. Ten patients (55.5%) gave birth in cohort A, 4 patients (40.0%) in cohort B, and 4 patients (28.5%) in cohort C. Given the small number of the included patients, there was no statistically significant difference identified in any of the followed cohorts through the completed statistical analysis. Conclusion: Intrauterine insertion of hyaluronan after the completed HSK adhesiolysis enabled the recovery of the normal menstrual cycle for 60.0% of the patients and improved the implantation rate (77.7%) and take home baby rate (55.5%), compared to the group of patients with insertion IUD and with the control group. ( J GYNECOL SURG 31:250) ER -
KRAJČOVIČOVÁ, Renáta, Robert HUDEČEK, Pavel VENTRUBA a Katarína SURGENTOVÁ. The Role of Hyaluronan in Asherman’s Syndrome Therapy. \textit{Journal of gynecologic surgery}. Larchmont: Mary Ann Liebert Inc., 2015, roč.~31, č.~5, s.~250-254. ISSN~1042-4067. Dostupné z: https://dx.doi.org/10.1089/gyn.2014.0129.
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