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@article{1317750,
author = {Trudu, Federica and Amato, Filippo and Vaňhara, Petr and Pivetta, Tiziana and PeñaandMéndez, E. M. and Havel, Josef},
article_location = {České Budějovice},
article_number = {2},
doi = {http://dx.doi.org/10.1016/j.jab.2015.03.003},
keywords = {Cancer; Coordination metal complexes; Cisplatin; Omics; Perspectives},
language = {eng},
issn = {1214-021X},
journal = {Journal of applied biomedicine},
title = {Coordination compounds in cancer: Past, present and perspectives},
volume = {13},
year = {2015}
}
TY - JOUR
ID - 1317750
AU - Trudu, Federica - Amato, Filippo - Vaňhara, Petr - Pivetta, Tiziana - Peña-Méndez, E. M. - Havel, Josef
PY - 2015
TI - Coordination compounds in cancer: Past, present and perspectives
JF - Journal of applied biomedicine
VL - 13
IS - 2
SP - 79-103
EP - 79-103
PB - Faculty of Health and Social Care, University of South Bohemia
SN - 1214021X
KW - Cancer
KW - Coordination metal complexes
KW - Cisplatin
KW - Omics
KW - Perspectives
N2 - Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.
ER -
TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ a Josef HAVEL. Coordination compounds in cancer: Past, present and perspectives. \textit{Journal of applied biomedicine}. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2015, roč.~13, č.~2, s.~79-103. ISSN~1214-021X. Dostupné z: https://dx.doi.org/10.1016/j.jab.2015.03.003.
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