Coordination compounds in cancer: Past, present and
perspectives

J 2015

Coordination compounds in cancer: Past, present and perspectives

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ et. al.

Základní údaje

Originální název

Coordination compounds in cancer: Past, present and perspectives

Autoři

TRUDU, Federica (380 Itálie, domácí), Filippo AMATO (380 Itálie, domácí), Petr VAŇHARA (203 Česká republika, domácí), Tiziana PIVETTA (380 Itálie), E. M. PEÑA-MÉNDEZ (724 Španělsko) a Josef HAVEL (203 Česká republika, garant, domácí)

Vydání

Journal of applied biomedicine, České Budějovice, Faculty of Health and Social Care, University of South Bohemia, 2015, 1214-021X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.509

Kód RIV

RIV/00216224:14310/15:00084756

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.jab.2015.03.003

UT WoS

000354949400002

Klíčová slova anglicky

Cancer; Coordination metal complexes; Cisplatin; Omics; Perspectives

Štítky

AKR, EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 19. 11. 2015 14:44, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.

Návaznosti

EE2.3.20.0185, projekt VaV

Název: Centrum analýz a modelování tkání a orgánů

MUNI/A/1558/2014, interní kód MU

Název: Zdroje pro tkáňové inženýrství 5 (Akronym: TissueEng5)

Investor: Masarykova univerzita, Zdroje pro tkáňové inženýrství 5, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ a Josef HAVEL. Coordination compounds in cancer: Past, present and perspectives. Journal of applied biomedicine. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2015, roč. 13, č. 2, s. 79-103. ISSN 1214-021X. Dostupné z: https://dx.doi.org/10.1016/j.jab.2015.03.003.

@article{1317750,
   author = {Trudu, Federica and Amato, Filippo and Vaňhara, Petr and Pivetta, Tiziana and PeñaandMéndez, E. M. and Havel, Josef},
   article_location = {České Budějovice},
   article_number = {2},
   doi = {http://dx.doi.org/10.1016/j.jab.2015.03.003},
   keywords = {Cancer; Coordination metal complexes; Cisplatin; Omics; Perspectives},
   language = {eng},
   issn = {1214-021X},
   journal = {Journal of applied biomedicine},
   title = {Coordination compounds in cancer: Past, present and perspectives},
   volume = {13},
   year = {2015}
}

TY  - JOUR
ID  - 1317750
AU  - Trudu, Federica - Amato, Filippo - Vaňhara, Petr - Pivetta, Tiziana - Peña-Méndez, E. M. - Havel, Josef
PY  - 2015
TI  - Coordination compounds in cancer: Past, present and perspectives
JF  - Journal of applied biomedicine
VL  - 13
IS  - 2
SP  - 79-103
EP  - 79-103
PB  - Faculty of Health and Social Care, University of South Bohemia
SN  - 1214021X
KW  - Cancer
KW  - Coordination metal complexes
KW  - Cisplatin
KW  - Omics
KW  - Perspectives
N2  - Metal-based coordination compounds have been used throughout the history of human medicine to treat various diseases, including cancer. Since the discovery of cisplatin in 1965, a great number of metal coordination complexes, such as platinum, ruthenium, gold or copper have been designed, synthesized and tested in order to develop clinically effective and safe drugs. Currently, many reviews cover applications of cytostatic metal complexes pointing out the most promising examples of platinum- and non-platinum-based compounds in preclinical and clinical trials. However, recent comprehensive reviews covering chemical and biological aspects of metal-based coordination compounds in cancer therapy are still rare. In this review we wish to provide an overview of the coordination chemistry of current and novel cytostatic compounds, including an outline of their design and rationale of synthesis, and summarize bio-chemical reactivity and physicochemical properties of candidate metal complexes.
ER  -

TRUDU, Federica, Filippo AMATO, Petr VAŇHARA, Tiziana PIVETTA, E. M. PEÑA-MÉNDEZ a Josef HAVEL. Coordination compounds in cancer: Past, present and perspectives. \textit{Journal of applied biomedicine}. České Budějovice: Faculty of Health and Social Care, University of South Bohemia, 2015, roč.~13, č.~2, s.~79-103. ISSN~1214-021X. Dostupné z: https://dx.doi.org/10.1016/j.jab.2015.03.003.

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