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@article{1318625,
author = {Shahidi, Khatibi M. and Křivánek, Jan and Kaukua, N. and Ernfors, P. and Hladik, L. and Kostal, V. and Masich, S. and Hampl, Aleš and Chubanov, V. and Gudermann, T. and Romanov, R.A. and Harkany, T. and Adameyko, I. and Fried, K.},
article_location = {Thousand Oaks},
article_number = {7},
doi = {http://dx.doi.org/10.1177/0022034515580796},
keywords = {pulp biology; dentinogenesis; growth/development; protein expression; transgenic animals; cell morphology},
language = {eng},
issn = {0022-0345},
journal = {Journal of Dental Research},
title = {Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts},
volume = {94},
year = {2015}
}
TY - JOUR
ID - 1318625
AU - Shahidi, Khatibi M. - Křivánek, Jan - Kaukua, N. - Ernfors, P. - Hladik, L. - Kostal, V. - Masich, S. - Hampl, Aleš - Chubanov, V. - Gudermann, T. - Romanov, R.A. - Harkany, T. - Adameyko, I. - Fried, K.
PY - 2015
TI - Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts
JF - Journal of Dental Research
VL - 94
IS - 7
SP - 945-954
EP - 945-954
PB - Sage Publication
SN - 00220345
KW - pulp biology
KW - dentinogenesis
KW - growth/development
KW - protein expression
KW - transgenic animals
KW - cell morphology
N2 - In organized tissues, the precise geometry and the overall shape are critical for the specialized functions that the cells carry out. Odontoblasts are major matrix-producing cells of the tooth and have also been suggested to participate in sensory transmission. However, refined morphologic data on these important cells are limited, which hampers the analysis and understanding of their cellular functions. We took advantage of fluorescent color-coding genetic tracing to visualize and reconstruct in 3 dimensions single odontoblasts, pulp cells, and their assemblages. Our results show distinct structural features and compartments of odontoblasts at different stages of maturation, with regard to overall cellular shape, formation of the main process, orientation, and matrix deposition. We demonstrate previously unanticipated contacts between the processes of pulp cells and odontoblasts. All reported data are related to mouse incisor tooth. We also show that odontoblasts express TRPM5 and Piezo2 ion channels. Piezo2 is expressed ubiquitously, while TRPM5 is asymmetrically distributed with distinct localization to regions proximal to and within odontoblast processes.
ER -
SHAHIDI, Khatibi M., Jan KŘIVÁNEK, N. KAUKUA, P. ERNFORS, L. HLADIK, V. KOSTAL, S. MASICH, Aleš HAMPL, V. CHUBANOV, T. GUDERMANN, R.A. ROMANOV, T. HARKANY, I. ADAMEYKO a K. FRIED. Three-dimensional Imaging Reveals New Compartments and Structural Adaptations in Odontoblasts. \textit{Journal of Dental Research}. Thousand Oaks: Sage Publication, 2015, roč.~94, č.~7, s.~945-954. ISSN~0022-0345. Dostupné z: https://dx.doi.org/10.1177/0022034515580796.
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