Impact of cognitive stimulation on ripples within human
epileptic and non-epileptic hippocampus

J 2015

Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus

BRÁZDIL, Milan, Jan CIMBÁLNÍK, Robert ROMAN, Daniel Joel SHAW, Matt M. STEAD et. al.

Základní údaje

Originální název

Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus

Autoři

BRÁZDIL, Milan (203 Česká republika, garant, domácí), Jan CIMBÁLNÍK (203 Česká republika), Robert ROMAN (203 Česká republika, domácí), Daniel Joel SHAW (826 Velká Británie a Severní Irsko, domácí), Matt M. STEAD (840 Spojené státy), Pavel DANIEL (203 Česká republika, domácí), Pavel JURÁK (203 Česká republika) a Josef HALÁMEK (203 Česká republika)

Vydání

BMC Neuroscience, LONDON, Biomed Central Ltd. 2015, 1471-2202

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.304

Kód RIV

RIV/00216224:14740/15:00081244

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1186/s12868-015-0184-0

UT WoS

000358412200001

Klíčová slova anglicky

High-frequency oscillations; Hippocampal ripples; Epilepsy; Human cognition

Štítky

EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 3. 2017 10:09, doc. MUDr. Robert Roman, Ph.D.

Anotace

V originále

Background: Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80-250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH). Methods: We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH. Results: Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only. Conclusion: Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

GAP103/11/0933, projekt VaV

Název: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Investor: Grantová agentura ČR, Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Přiložené soubory

EL_1318806.pdf

Požádat o autorskou verzi souboru

1318806_Impact_of_cognitive.pdf

Požádat o autorskou verzi souboru

Citovat

BRÁZDIL, Milan, Jan CIMBÁLNÍK, Robert ROMAN, Daniel Joel SHAW, Matt M. STEAD, Pavel DANIEL, Pavel JURÁK a Josef HALÁMEK. Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus. BMC Neuroscience. LONDON: Biomed Central Ltd., 2015, roč. 16, july, s. "nestránkováno", 9 s. ISSN 1471-2202. Dostupné z: https://dx.doi.org/10.1186/s12868-015-0184-0.

@article{1318806,
   author = {Brázdil, Milan and Cimbálník, Jan and Roman, Robert and Shaw, Daniel Joel and Stead, Matt M. and Daniel, Pavel and Jurák, Pavel and Halámek, Josef},
   article_location = {LONDON},
   article_number = {july},
   doi = {http://dx.doi.org/10.1186/s12868-015-0184-0},
   keywords = {High-frequency oscillations; Hippocampal ripples; Epilepsy; Human cognition},
   language = {eng},
   issn = {1471-2202},
   journal = {BMC Neuroscience},
   title = {Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus},
   url = {http://www.biomedcentral.com/content/pdf/s12868-015-0184-0.pdf},
   volume = {16},
   year = {2015}
}

TY  - JOUR
ID  - 1318806
AU  - Brázdil, Milan - Cimbálník, Jan - Roman, Robert - Shaw, Daniel Joel - Stead, Matt M. - Daniel, Pavel - Jurák, Pavel - Halámek, Josef
PY  - 2015
TI  - Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus
JF  - BMC Neuroscience
VL  - 16
IS  - july
SP  - "nestránkováno"
EP  - "nestránkováno"
PB  - Biomed Central Ltd.
SN  - 14712202
KW  - High-frequency oscillations
KW  - Hippocampal ripples
KW  - Epilepsy
KW  - Human cognition
UR  - http://www.biomedcentral.com/content/pdf/s12868-015-0184-0.pdf
L2  - http://www.biomedcentral.com/content/pdf/s12868-015-0184-0.pdf
N2  - Background: Until now there has been no way of distinguishing between physiological and epileptic hippocampal ripples in intracranial recordings. In the present study we addressed this by investigating the effect of cognitive stimulation on interictal high frequency oscillations in the ripple range (80-250 Hz) within epileptic (EH) and non-epileptic hippocampus (NH). Methods: We analyzed depth EEG recordings in 10 patients with intractable epilepsy, in whom hippocampal activity was recorded initially during quiet wakefulness and subsequently during a simple cognitive task. Using automated detection of ripples based on amplitude of the power envelope, we analyzed ripple rate (RR) in the cognitive and resting period, within EH and NH. Results: Compared to quiet wakefulness we observed a significant reduction of RR during cognitive stimulation in EH, while it remained statistically marginal in NH. Further, we investigated the direct impact of cognitive stimuli on ripples (i.e. immediately post-stimulus), which showed a transient statistically significant suppression of ripples in the first second after stimuli onset in NH only. Conclusion: Our results point to a differential reactivity of ripples within EH and NH to cognitive stimulation.
ER  -

BRÁZDIL, Milan, Jan CIMBÁLNÍK, Robert ROMAN, Daniel Joel SHAW, Matt M. STEAD, Pavel DANIEL, Pavel JURÁK a Josef HALÁMEK. Impact of cognitive stimulation on ripples within human epileptic and non-epileptic hippocampus. \textit{BMC Neuroscience}. LONDON: Biomed Central Ltd., 2015, roč.~16, july, s.~''nestránkováno'', 9 s. ISSN~1471-2202. Dostupné z: https://dx.doi.org/10.1186/s12868-015-0184-0.

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