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@inbook{1319460,
author = {Juřica, Jan and Turjap, Miroslav and Nosková, Kristýna},
address = {New York},
booktitle = {Dextromethorphan: Pharmacology, Clinical Uses and Health Effects},
editor = {Xin Wang},
keywords = {dextromethorphan; CYP3A4; CYP2D6; metabolic phenotype},
howpublished = {elektronická verze "online"},
language = {eng},
location = {New York},
isbn = {978-1-63484-024-8},
pages = {137-151},
publisher = {Nova Science Publishers},
title = {Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping},
year = {2015}
}
TY - CHAP
ID - 1319460
AU - Juřica, Jan - Turjap, Miroslav - Nosková, Kristýna
PY - 2015
TI - Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping
VL - Nova Biomedical
PB - Nova Science Publishers
CY - New York
SN - 9781634840248
KW - dextromethorphan
KW - CYP3A4
KW - CYP2D6
KW - metabolic phenotype
N2 - Chapter summarizes the use of dextromethorphan as a marker substrate for CYP2D6 and CYP3A4 metabolic activity determination. The ratio of the concentration of the specific substrate to the metabolite(s) in various biological matrices (saliva, plasma/serum, urine) is the most widely used methodological approach to assess metabolic activity in vivo.
ER -
JUŘICA, Jan, Miroslav TURJAP and Kristýna NOSKOVÁ. Dextromethorphan as a Probe Drug for CYP2D6 and CYP3A4 Phenotyping. Online. In Xin Wang. \textit{Dextromethorphan: Pharmacology, Clinical Uses and Health Effects}. New York: Nova Science Publishers, 2015, p.~137-151. Nova Biomedical. ISBN~978-1-63484-024-8.
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