2016
Linking Essential Tremor to the Cerebellum: Physiological Evidence
FILIP, Pavel, Ovidiu V. LUNGU, Mario-Ubaldo MANTO a Martin BAREŠZákladní údaje
Originální název
Linking Essential Tremor to the Cerebellum: Physiological Evidence
Autoři
FILIP, Pavel (703 Slovensko, domácí), Ovidiu V. LUNGU (124 Kanada), Mario-Ubaldo MANTO (56 Belgie) a Martin BAREŠ (203 Česká republika, garant, domácí)
Vydání
Cerebellum, New York, Springer, 2016, 1473-4222
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30000 3. Medical and Health Sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 3.234
Kód RIV
RIV/00216224:14110/16:00089199
Organizační jednotka
Lékařská fakulta
UT WoS
000387539000013
Klíčová slova anglicky
Cerebellum; Essential tremor; Dynamic oscillatory network; Electrophysiology
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 19. 12. 2016 15:23, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Essential tremor (ET), clinically characterized by postural and kinetic tremors, predominantly in the upper extremities, originates from pathological activity in the dynamic oscillatory network comprising the majority of nodes in the central motor network. Evidence indicates dysfunction in the thalamus, the olivocerebellar loops, and intermittent cortical engagement. Pathology of the cerebellum, a structure with architecture intrinsically predisposed to oscillatory activity, has also been implicated in ET as shown by clinical, neuroimaging, and pathological studies. Despite electrophysiological studies assessing cerebellar impairment in ET being scarce, their impact is tangible, as summarized in this review. The electromyography–magnetoencephalography combination provided the first direct evidence of pathological alteration in cortico-subcortical communication, with a significant emphasis on the cerebellum. Furthermore, complex electromyography studies showed disruptions in the timing of agonist and antagonist muscle activation, a process generally attributed to the cerebellum. Evidence pointing to cerebellar engagement in ET has also been found in electrooculography measurements, cerebellar repetitive transcranial magnetic stimulation studies, and, indirectly, in complex analyses of the activity of the ventral intermediate thalamic nucleus (an area primarily receiving inputs from the cerebellum), which is also used in the advanced treatment of ET. In summary, further progress in therapy will require comprehensive electrophysiological and physiological analyses to elucidate the precise mechanisms leading to disease symptoms. The cerebellum, as a major node of this dynamic oscillatory network, requires further study to aid this endeavor.
Návaznosti
ED1.1.00/02.0068, projekt VaV |
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