Interleukin-6 May Contribute to Mortality in Parkinson's
Disease Patients: A 4-Year Prospective Study

J 2015

Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ, Ivan REKTOR et. al.

Základní údaje

Originální název

Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study

Autoři

DUFEK, Michal (203 Česká republika, garant), Irena REKTOROVÁ (203 Česká republika, domácí), Vojtěch THON (203 Česká republika, domácí), Jindřich LOKAJ (203 Česká republika, domácí) a Ivan REKTOR (203 Česká republika, domácí)

Vydání

Parkinsons Disease, New York, Hindawi Publishing Corporation, 2015, 2090-8083

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 1.722

Kód RIV

RIV/00216224:14110/15:00085127

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1155/2015/898192

UT WoS

000360499700001

Klíčová slova anglicky

GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6

Štítky

EL OK, kontrola MP, ok, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 10. 2. 2016 18:17, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Přiložené soubory

EL_1320444.pdf

Požádat o autorskou verzi souboru

Citovat

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ a Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. Parkinsons Disease. New York: Hindawi Publishing Corporation, 2015, roč. 2015, č. 898192, s. 1-5. ISSN 2090-8083. Dostupné z: https://dx.doi.org/10.1155/2015/898192.

@article{1320444,
   author = {Dufek, Michal and Rektorová, Irena and Thon, Vojtěch and Lokaj, Jindřich and Rektor, Ivan},
   article_location = {New York},
   article_number = {898192},
   doi = {http://dx.doi.org/10.1155/2015/898192},
   keywords = {GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6},
   language = {eng},
   issn = {2090-8083},
   journal = {Parkinsons Disease},
   title = {Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study},
   url = {http://www.hindawi.com/journals/pd/2015/898192/},
   volume = {2015},
   year = {2015}
}

TY  - JOUR
ID  - 1320444
AU  - Dufek, Michal - Rektorová, Irena - Thon, Vojtěch - Lokaj, Jindřich - Rektor, Ivan
PY  - 2015
TI  - Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study
JF  - Parkinsons Disease
VL  - 2015
IS  - 898192
SP  - 1-5
EP  - 1-5
PB  - Hindawi Publishing Corporation
SN  - 20908083
KW  - GROWTH-FACTOR-ALPHA
KW  - C-REACTIVE PROTEIN
KW  - CEREBROSPINAL-FLUID
KW  - CYTOKINE PRODUCTION
KW  - ATHEROSCLEROSIS
KW  - INFLAMMATION
KW  - RISK
KW  - HEALTH
KW  - BRAIN
KW  - IL-6
UR  - http://www.hindawi.com/journals/pd/2015/898192/
N2  - Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology.
ER  -

DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ a Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. \textit{Parkinsons Disease}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, č.~898192, s.~1-5. ISSN~2090-8083. Dostupné z: https://dx.doi.org/10.1155/2015/898192.

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