DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ a Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. Parkinsons Disease. New York: Hindawi Publishing Corporation, 2015, roč. 2015, č. 898192, s. 1-5. ISSN 2090-8083. Dostupné z: https://dx.doi.org/10.1155/2015/898192. |
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@article{1320444, author = {Dufek, Michal and Rektorová, Irena and Thon, Vojtěch and Lokaj, Jindřich and Rektor, Ivan}, article_location = {New York}, article_number = {898192}, doi = {http://dx.doi.org/10.1155/2015/898192}, keywords = {GROWTH-FACTOR-ALPHA; C-REACTIVE PROTEIN; CEREBROSPINAL-FLUID; CYTOKINE PRODUCTION; ATHEROSCLEROSIS; INFLAMMATION; RISK; HEALTH; BRAIN; IL-6}, language = {eng}, issn = {2090-8083}, journal = {Parkinsons Disease}, title = {Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study}, url = {http://www.hindawi.com/journals/pd/2015/898192/}, volume = {2015}, year = {2015} }
TY - JOUR ID - 1320444 AU - Dufek, Michal - Rektorová, Irena - Thon, Vojtěch - Lokaj, Jindřich - Rektor, Ivan PY - 2015 TI - Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study JF - Parkinsons Disease VL - 2015 IS - 898192 SP - 1-5 EP - 1-5 PB - Hindawi Publishing Corporation SN - 20908083 KW - GROWTH-FACTOR-ALPHA KW - C-REACTIVE PROTEIN KW - CEREBROSPINAL-FLUID KW - CYTOKINE PRODUCTION KW - ATHEROSCLEROSIS KW - INFLAMMATION KW - RISK KW - HEALTH KW - BRAIN KW - IL-6 UR - http://www.hindawi.com/journals/pd/2015/898192/ N2 - Objectives. The association between abnormal serum immunomarkers and mortality in 53 consecutive Parkinson's disease patients was studied. Materials and Methods. The plasma level of specific inflammatory cytokines was investigated: mannan-binding lectin (MBL), interleukin-(IL-) 6, and tumor necrosis factor-alpha (TNF-alpha). The baseline serum immunomarkers obtained from patients who died (n = 16) during a four-year follow-up period were compared with the data of patients who survived (n = 37). Results. The baseline level of IL-6 was significantly higher in the deceased patients than in the survivors. Elevated IL-6 levels and age were major independent contributors to disease mortality. Differences between other plasma cytokine level abnormalities were not significant. Conclusion. This study showed that IL-6 elevation may be a marker of increased mortality risk in Parkinson's disease patients. The inflammation may act in association with other factors and comorbidities in progressive neurodegenerative pathology. ER -
DUFEK, Michal, Irena REKTOROVÁ, Vojtěch THON, Jindřich LOKAJ a Ivan REKTOR. Interleukin-6 May Contribute to Mortality in Parkinson's Disease Patients: A 4-Year Prospective Study. \textit{Parkinsons Disease}. New York: Hindawi Publishing Corporation, 2015, roč.~2015, č.~898192, s.~1-5. ISSN~2090-8083. Dostupné z: https://dx.doi.org/10.1155/2015/898192.
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