The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate
in Memory Processing: An Intracerebral Recording Study

J 2015

The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study

ŠTILLOVÁ, Klára, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK et. al.

Basic information

Original name

The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study

Authors

ŠTILLOVÁ, Klára (703 Slovakia, belonging to the institution), Pavel JURÁK (203 Czech Republic), Jan CHLÁDEK (203 Czech Republic), Jan CHRASTINA (203 Czech Republic, belonging to the institution), Josef HALÁMEK (203 Czech Republic), Martina BOČKOVÁ (203 Czech Republic, belonging to the institution), Sabina GOLDEMUNDOVÁ (203 Czech Republic, belonging to the institution), Ivo ŘÍHA (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

PLOS ONE, San Francisco, Public Library of Science, 2015, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.057

RIV identification code

RIV/00216224:14740/15:00081297

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1371/journal.pone.0140778

UT WoS

000364032600012

Keywords in English

ANT; anterior nuclein of the thalamus; deep brain stimulation; epilepsy

Abstract

V originále

Objective To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks. Methods We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks. Results P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus. Conclusions The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.

Links

ED1.1.00/02.0068, research and development project

Name: CEITEC - central european institute of technology

GAP103/11/0933, research and development project

Name: Analýza vysokofrekvenčního EEG signálu z hlubokých mozkových elektrod

Investor: Czech Science Foundation

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Citovat

ŠTILLOVÁ, Klára, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Ivo ŘÍHA and Ivan REKTOR. The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study. PLOS ONE. San Francisco: Public Library of Science, 2015, vol. 10, No 11, p. nestránkováno, 13 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0140778.

@article{1320451,
   author = {Štillová, Klára and Jurák, Pavel and Chládek, Jan and Chrastina, Jan and Halámek, Josef and Bočková, Martina and Goldemundová, Sabina and Říha, Ivo and Rektor, Ivan},
   article_location = {San Francisco},
   article_number = {11},
   doi = {http://dx.doi.org/10.1371/journal.pone.0140778},
   keywords = {ANT; anterior nuclein of the thalamus; deep brain stimulation; epilepsy},
   language = {eng},
   issn = {1932-6203},
   journal = {PLOS ONE},
   title = {The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study},
   url = {http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140778},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1320451
AU  - Štillová, Klára - Jurák, Pavel - Chládek, Jan - Chrastina, Jan - Halámek, Josef - Bočková, Martina - Goldemundová, Sabina - Říha, Ivo - Rektor, Ivan
PY  - 2015
TI  - The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study
JF  - PLOS ONE
VL  - 10
IS  - 11
SP  - nestránkováno
EP  - nestránkováno
PB  - Public Library of Science
SN  - 19326203
KW  - ANT
KW  - anterior nuclein of the thalamus
KW  - deep brain stimulation
KW  - epilepsy
UR  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140778
L2  - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140778
N2  - Objective To study the involvement of the anterior nuclei of the thalamus (ANT) as compared to the involvement of the hippocampus in the processes of encoding and recognition during visual and verbal memory tasks. Methods We studied intracerebral recordings in patients with pharmacoresistent epilepsy who underwent deep brain stimulation (DBS) of the ANT with depth electrodes implanted bilaterally in the ANT and compared the results with epilepsy surgery candidates with depth electrodes implanted bilaterally in the hippocampus. We recorded the event-related potentials (ERPs) elicited by the visual and verbal memory encoding and recognition tasks. Results P300-like potentials were recorded in the hippocampus by visual and verbal memory encoding and recognition tasks and in the ANT by the visual encoding and visual and verbal recognition tasks. No significant ERPs were recorded during the verbal encoding task in the ANT. In the visual and verbal recognition tasks, the P300-like potentials in the ANT preceded the P300-like potentials in the hippocampus. Conclusions The ANT is a structure in the memory pathway that processes memory information before the hippocampus. We suggest that the ANT has a specific role in memory processes, especially memory recognition, and that memory disturbance should be considered in patients with ANT-DBS and in patients with ANT lesions. ANT is well positioned to serve as a subcortical gate for memory processing in cortical structures.
ER  -

ŠTILLOVÁ, Klára, Pavel JURÁK, Jan CHLÁDEK, Jan CHRASTINA, Josef HALÁMEK, Martina BOČKOVÁ, Sabina GOLDEMUNDOVÁ, Ivo ŘÍHA and Ivan REKTOR. The Role of Anterior Nuclei of the Thalamus: A Subcortical Gate in Memory Processing: An Intracerebral Recording Study. \textit{PLOS ONE}. San Francisco: Public Library of Science, 2015, vol.~10, No~11, p.~nestránkováno, 13 pp. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0140778.

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