| VALLEJO-VAZ, Antonio J., Sreenivasa Rao K. SESHASAI, Della COLE, G Kees HOVINGH, John J. P. KASTELEIN, Pedro MATA, Frederick J. RAAL, Raul D. SANTOS, Handrean SORAN, Gerald F. WATTS, Marianne ABIFADEL, Carlos A. AGUILAR-SALINAS, Asif AKRAM, Fahad ALNOURI, Rodrigo ALONSO, Khalid AL-RASADI, Maciej BANACH, Martin P. BOGSRUD, Mafalda BOURBON, Eric BRUCKERT, Josip CAR, Pablo CORRAL, Olivier DESCAMPS, Hans DIEPLINGER, Ronen DURST, Tomáš FREIBERGER, Isabela M. GASPAR, Jaques GENEST, Mariko HARADA-SHIBA, Lixin JIANG, Meral KAYIKCIOGLU, Carolyn S. P. LAM, Gustavs LATKOVSKIS, Ulrich LAUFS, Evangelos LIBEROPOULOS, Lennart NILSSON, Børge G. NORDESTGAARD, John M. O´DONOGHUE, Amirhossein SAHEBKAR, Heribert SCHUNKERT, Abdulla SHEHAB, Mario STOLL, Ta-Chen SU, Andrey SUSEKOV, Elisabeth WIDÉN, Alberico L. CATAPANO a Kausik K. RAY. Familial hypercholesterolaemia: A global call to arms. Atherosclerosis. Clare (Irsko): ELSEVIER SCI IRELAND LTD, 2015, roč. 243, č. 1, s. 257-259. ISSN 0021-9150. Dostupné z: https://dx.doi.org/10.1016/j.atherosclerosis.2015.09.021. |
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@article{1320508,
author = {VallejoandVaz, Antonio J. and Seshasai, Sreenivasa Rao K. and Cole, Della and Hovingh, G Kees and Kastelein, John J. P. and Mata, Pedro and Raal, Frederick J. and Santos, Raul D. and Soran, Handrean and Watts, Gerald F. and Abifadel, Marianne and AguilarandSalinas, Carlos A. and Akram, Asif and Alnouri, Fahad and Alonso, Rodrigo and AlandRasadi, Khalid and Banach, Maciej and Bogsrud, Martin P. and Bourbon, Mafalda and Bruckert, Eric and Car, Josip and Corral, Pablo and Descamps, Olivier and Dieplinger, Hans and Durst, Ronen and Freiberger, Tomáš and Gaspar, Isabela M. and Genest, Jaques and HaradaandShiba, Mariko and Jiang, Lixin and Kayikcioglu, Meral and Lam, Carolyn S. P. and Latkovskis, Gustavs and Laufs, Ulrich and Liberopoulos, Evangelos and Nilsson, Lennart and Nordestgaard, Børge G. and O´Donoghue, John M. and Sahebkar, Amirhossein and Schunkert, Heribert and Shehab, Abdulla and Stoll, Mario and Su, TaandChen and Susekov, Andrey and Widén, Elisabeth and Catapano, Alberico L. and Ray, Kausik K.},
article_location = {Clare (Irsko)},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.atherosclerosis.2015.09.021},
keywords = {Familial hypercholesterolaemia; disease; Prevalence},
language = {eng},
issn = {0021-9150},
journal = {Atherosclerosis},
title = {Familial hypercholesterolaemia: A global call to arms},
url = {http://ac.els-cdn.com/S0021915015301301/1-s2.0-S0021915015301301-main.pdf?_tid=027dcd06-9e40-11e5-83c4-00000aacb361&acdnat=1449643526_89ab5894d31f4df6fd618f2c0be660c6},
volume = {243},
year = {2015}
}
TY - JOUR
ID - 1320508
AU - Vallejo-Vaz, Antonio J. - Seshasai, Sreenivasa Rao K. - Cole, Della - Hovingh, G Kees - Kastelein, John J. P. - Mata, Pedro - Raal, Frederick J. - Santos, Raul D. - Soran, Handrean - Watts, Gerald F. - Abifadel, Marianne - Aguilar-Salinas, Carlos A. - Akram, Asif - Alnouri, Fahad - Alonso, Rodrigo - Al-Rasadi, Khalid - Banach, Maciej - Bogsrud, Martin P. - Bourbon, Mafalda - Bruckert, Eric - Car, Josip - Corral, Pablo - Descamps, Olivier - Dieplinger, Hans - Durst, Ronen - Freiberger, Tomáš - Gaspar, Isabela M. - Genest, Jaques - Harada-Shiba, Mariko - Jiang, Lixin - Kayikcioglu, Meral - Lam, Carolyn S. P. - Latkovskis, Gustavs - Laufs, Ulrich - Liberopoulos, Evangelos - Nilsson, Lennart - Nordestgaard, Børge G. - O´Donoghue, John M. - Sahebkar, Amirhossein - Schunkert, Heribert - Shehab, Abdulla - Stoll, Mario - Su, Ta-Chen - Susekov, Andrey - Widén, Elisabeth - Catapano, Alberico L. - Ray, Kausik K.
PY - 2015
TI - Familial hypercholesterolaemia: A global call to arms
JF - Atherosclerosis
VL - 243
IS - 1
SP - 257-259
EP - 257-259
PB - ELSEVIER SCI IRELAND LTD
SN - 00219150
KW - Familial hypercholesterolaemia
KW - disease
KW - Prevalence
UR - http://ac.els-cdn.com/S0021915015301301/1-s2.0-S0021915015301301-main.pdf?_tid=027dcd06-9e40-11e5-83c4-00000aacb361&acdnat=1449643526_89ab5894d31f4df6fd618f2c0be660c6
L2 - http://ac.els-cdn.com/S0021915015301301/1-s2.0-S0021915015301301-main.pdf?_tid=027dcd06-9e40-11e5-83c4-00000aacb361&acdnat=1449643526_89ab5894d31f4df6fd618f2c0be660c6
N2 - Familial Hypercholesterolaemia (FH) is the commonest autosomal co-dominantly inherited condition affecting man. It is caused by mutation in one of three genes, encoding the low-density lipoprotein (LDL) receptor, or the gene for apolipoprotein B (which is the major protein component of the LDL particle), or in the gene coding for PCSK9 (which is involved in the degradation of the LDL-receptor during its cellular recycling). These mutations result in impaired LDL metabolism, leading to life-long elevations in LDL-cholesterol (LDL-C) and development of premature atherosclerotic cardiovascular disease (ASCVD) [1], [2] and [3]. If left untreated, the relative risk of premature coronary artery disease is significantly higher in heterozygous patients than unaffected individuals, with most untreated homozygotes developing ASCVD before the age of 20 and generally not surviving past 30 years [2], [3], [4] and [5]. Although early detection and treatment with statins and other LDL-C lowering therapies can improve survival, FH remains widely underdiagnosed and undertreated [1], thereby representing a major global public health challenge.
ER -
VALLEJO-VAZ, Antonio J., Sreenivasa Rao K. SESHASAI, Della COLE, G Kees HOVINGH, John J. P. KASTELEIN, Pedro MATA, Frederick J. RAAL, Raul D. SANTOS, Handrean SORAN, Gerald F. WATTS, Marianne ABIFADEL, Carlos A. AGUILAR-SALINAS, Asif AKRAM, Fahad ALNOURI, Rodrigo ALONSO, Khalid AL-RASADI, Maciej BANACH, Martin P. BOGSRUD, Mafalda BOURBON, Eric BRUCKERT, Josip CAR, Pablo CORRAL, Olivier DESCAMPS, Hans DIEPLINGER, Ronen DURST, Tomáš FREIBERGER, Isabela M. GASPAR, Jaques GENEST, Mariko HARADA-SHIBA, Lixin JIANG, Meral KAYIKCIOGLU, Carolyn S. P. LAM, Gustavs LATKOVSKIS, Ulrich LAUFS, Evangelos LIBEROPOULOS, Lennart NILSSON, Børge G. NORDESTGAARD, John M. O´DONOGHUE, Amirhossein SAHEBKAR, Heribert SCHUNKERT, Abdulla SHEHAB, Mario STOLL, Ta-Chen SU, Andrey SUSEKOV, Elisabeth WIDÉN, Alberico L. CATAPANO a Kausik K. RAY. Familial hypercholesterolaemia: A global call to arms. \textit{Atherosclerosis}. Clare (Irsko): ELSEVIER SCI IRELAND LTD, 2015, roč.~243, č.~1, s.~257-259. ISSN~0021-9150. Dostupné z: https://dx.doi.org/10.1016/j.atherosclerosis.2015.09.021.
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