2015
Increased Cardio-ankle Vascular Index in Hyperlipidemic Patients without Diabetes or Hypertension
DOBŠÁK, Petr, Vladimír SOŠKA, Ondřej SOCHOR, Jiří JARKOVSKÝ, Marie NOVÁKOVÁ et. al.Základní údaje
Originální název
Increased Cardio-ankle Vascular Index in Hyperlipidemic Patients without Diabetes or Hypertension
Autoři
DOBŠÁK, Petr (203 Česká republika, domácí), Vladimír SOŠKA (203 Česká republika, garant, domácí), Ondřej SOCHOR (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí), Marie NOVÁKOVÁ (203 Česká republika, domácí), Martin HOMOLKA (203 Česká republika), Miroslav SOUČEK (203 Česká republika, domácí), Petra PALANOVÁ (203 Česká republika, domácí), Francisco LOPEZ-JIMENEZ (840 Spojené státy) a Kohji SHIRAI (392 Japonsko)
Vydání
Journal of Atherosclerosis and Thrombosis, Tokyo, Japan Atherosclerosis Society, 2015, 1340-3478
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30201 Cardiac and Cardiovascular systems
Stát vydavatele
Japonsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.411
Kód RIV
RIV/00216224:14110/15:00085181
Organizační jednotka
Lékařská fakulta
UT WoS
000352271200008
Klíčová slova anglicky
Cardio-ankle vascular index; Combined hyperlipidemia; Hypercholesterolemia
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 27. 1. 2016 12:01, Ing. Mgr. Věra Pospíšilíková
Anotace
V originále
Aim: The cardio-ankle vascular index (CAVI) is a sensitive non-invasive marker of arterial stiffness and atherosclerosis. The aim of this work was to compare the CAVI values in patients with dyslipidemia (without diabetes mellitus and hypertension) and healthy controls. Methods: A Total 248 subjects with dyslipidemia (104 men, 144 women), 55.0 (95% CI 30-70) years of age with combined hyperlipidemia or primary hypercholesterolemia and 537 healthy controls (244 men, 293 women) 40.0 (95% CI 26-62) years of age were included in this study. Fasting blood samples were collected to measure the serum total cholesterol, triglyceride, HDL-cholesterol and apolipoprotein A1 and B levels. The LDL cholesterol level was also calculated, and the CAVI was measured using the VaSera (R) 1500 system. Results: The CAVI values were significantly higher in the dyslipidemic patients (8.08, 95% CI 6.00-10.05) than in the controls (7.11, 95% CI 5.77-9.05; p<0.01). In addition, the CAVI values were elevated in both subgroups of patients with hypercholesterolemia (7.95, 95% CI 5.85-6.90; p<0.01) and combined hyperlipidemia (8.30, 95% CI 6.60-10.15; p<0.01) in comparison with those observed in the controls. After adopting the propensity score method in order to balance the confounding factors (age, gender, body mass index) and adjust the analysis for diastolic blood pressure, the CAVI values in the dyslipidemic patients remained significantly high (7.78, 95% CI 5.80-9.69) compared to that observed in the controls (7.31, 95% CI 5.44-9.35; p<0.001). However, the CAVI values did not differ significantly between the controls and both subgroups of dyslipidemic patients (primary hypercholesterolemia, combined hyperlipidemia). Conclusions: The present findings demonstrated that dyslipidemia increases the CAVI values in comparison to that seen in healthy subjects.