Using ASL Method for Monitoring of Brain Perfusion Changes in a
Rat Model of Schizophrenia and After Chronic Administration of
Aripiprazole.

D 2015

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ et. al.

Základní údaje

Originální název

Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.

Autoři

DRAŽANOVÁ, Eva (203 Česká republika, garant, domácí), Lucie GROSSOVÁ (203 Česká republika), Jana PISTOVČÁKOVÁ (203 Česká republika, domácí), Amit Suresh KHAIRNAR (203 Česká republika, domácí), Regina DEMLOVÁ (203 Česká republika, domácí), Tomáš KAŠPÁREK (203 Česká republika, domácí) a Zenon STARČUK (203 Česká republika, domácí)

Vydání

Bratislava, Measurement 2015 : Proceedings of the 10th International Conference on Measurement, od s. 81-84, 4 s. 2015

Nakladatel

Institute of Measurement Science, SAS

Další údaje

Jazyk

angličtina

Typ výsledku

Stať ve sborníku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Forma vydání

tištěná verze "print"

Odkazy

URL

Kód RIV

RIV/00216224:14110/15:00095810

Organizační jednotka

Lékařská fakulta

ISBN

978-80-969672-9-2

Klíčová slova anglicky

ASL; schizophrenia; poly I:C animal model; rats; aripiprazole

Štítky

EL OK

Změněno: 15. 5. 2018 16:49, Soňa Böhmová

Anotace

V originále

Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.

Návaznosti

LM2011017, projekt VaV

Název: Advanced Cell Immunotherapy Unit - ACIU

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Advanced cell immunotherapy unit BVI-ACIU

MUNI/A/1116/2014, interní kód MU

Název: Nové farmakologické mechanizmy v preklinickém i klinickém vývoji léčiv

Investor: Masarykova univerzita, Nové farmakologické mechanizmy v preklinickém i klinickém vývoji léčiv, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ, Tomáš KAŠPÁREK a Zenon STARČUK. Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole. In Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo. Measurement 2015 : Proceedings of the 10th International Conference on Measurement. Bratislava: Institute of Measurement Science, SAS, 2015, s. 81-84. ISBN 978-80-969672-9-2.

@inproceedings{1321601,
   author = {Dražanová, Eva and Grossová, Lucie and Pistovčáková, Jana and Khairnar, Amit Suresh and Demlová, Regina and Kašpárek, Tomáš and Starčuk, Zenon},
   address = {Bratislava},
   booktitle = {Measurement 2015 : Proceedings of the 10th International Conference on Measurement},
   editor = {Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo},
   keywords = {ASL; schizophrenia; poly I:C animal model; rats; aripiprazole},
   howpublished = {tištěná verze "print"},
   language = {eng},
   location = {Bratislava},
   isbn = {978-80-969672-9-2},
   pages = {81-84},
   publisher = {Institute of Measurement Science, SAS},
   title = {Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.},
   url = {http://hdl.handle.net/11104/0248090},
   year = {2015}
}

TY  - JOUR
ID  - 1321601
AU  - Dražanová, Eva - Grossová, Lucie - Pistovčáková, Jana - Khairnar, Amit Suresh - Demlová, Regina - Kašpárek, Tomáš - Starčuk, Zenon
PY  - 2015
TI  - Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole.
PB  - Institute of Measurement Science, SAS
CY  - Bratislava
SN  - 9788096967292
KW  - ASL
KW  - schizophrenia
KW  - poly I:C animal model
KW  - rats
KW  - aripiprazole
UR  - http://hdl.handle.net/11104/0248090
N2  - Animals prenatally exposed to polyriboinosinic–polyribocytidilic acid (poly I:C) can be used to parallel neuropathological abnormalities seen in schizophrenia patients. The aim of this study was to test the utility of Arterial Spin Labeling (ASL) MRI method for the evaluation of perfusion in different brain regions in the developmental poly I:C model of schizophrenia in rats. In these animals we further investigated the effect of chronic administration of the antipsychotic aripiprazole on brain perfusion. In the circle of Willis region, we observed significant increase of blood perfusion in the poly I:C model of schizophrenia in both males and females, and significantly higher perfusion in males than in females in vehicle-treated controls. Perfusion in hippocampus (in both hemispheres) was found significantly higher in males than in females in both vehicle-treated controls and poly I:C prenatally exposed animals. The significantly increased blood perfusion in the circle of Willis in poly I:C prenatally exposed males was found to persist even after chronic administration of aripiprazole. These results add new data to understanding of antipsychotic effects and demonstrate the viability of the proposed approach of combination of the ASL MRI method and the selected rat model of schizophrenia.
ER  -

DRAŽANOVÁ, Eva, Lucie GROSSOVÁ, Jana PISTOVČÁKOVÁ, Amit Suresh KHAIRNAR, Regina DEMLOVÁ, Tomáš KAŠPÁREK a Zenon STARČUK. Using ASL Method for Monitoring of Brain Perfusion Changes in a Rat Model of Schizophrenia and After Chronic Administration of Aripiprazole. In Ján Maňka, Milan Tyšler, Vikor Witkovský, Ivan Frollo. \textit{Measurement 2015 : Proceedings of the 10th International Conference on Measurement}. Bratislava: Institute of Measurement Science, SAS, 2015, s.~81-84. ISBN~978-80-969672-9-2.

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