Impact of Parkinson's disease and levodopa on resting state
functional connectivity related to speech prosody control

J 2016

Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control

ELFMARKOVÁ, Nela, Martin GAJDOŠ, Martina MRAČKOVÁ, Jiří MEKYSKA, Michal MIKL et. al.

Základní údaje

Originální název

Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control

Autoři

ELFMARKOVÁ, Nela (203 Česká republika, domácí), Martin GAJDOŠ (203 Česká republika, domácí), Martina MRAČKOVÁ (203 Česká republika, domácí), Jiří MEKYSKA (203 Česká republika), Michal MIKL (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2016, 1353-8020

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30000 3. Medical and Health Sciences

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.484

Kód RIV

RIV/00216224:14740/16:00088836

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1016/j.parkreldis.2015.09.006

UT WoS

000366781900012

Klíčová slova anglicky

Parkinson's disease; Functional connectivity; Speech prosody; fMRI; Resting state; Dopaminergic; Levodopa; Acoustic; Motor speech network; Caudate nucleus

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 16. 12. 2016 10:17, Mgr. Eva Špillingová

Anotace

V originále

Background: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. Methods: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. Results: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. Conclusions: We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found. (C) 2015 Elsevier Ltd. All rights reserved.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

NT13499, projekt VaV

Název: Řeč, její poruchy a kognitivní funkce u Parkinsonovy nemoci

Citovat

ELFMARKOVÁ, Nela, Martin GAJDOŠ, Martina MRAČKOVÁ, Jiří MEKYSKA, Michal MIKL a Irena REKTOROVÁ. Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2016, roč. 22, Supplement 1, s. "S52"-"S55", 4 s. ISSN 1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2015.09.006.

@article{1321778,
   author = {Elfmarková, Nela and Gajdoš, Martin and Mračková, Martina and Mekyska, Jiří and Mikl, Michal and Rektorová, Irena},
   article_location = {OXFORD},
   article_number = {Supplement 1},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2015.09.006},
   keywords = {Parkinson's disease; Functional connectivity; Speech prosody; fMRI; Resting state; Dopaminergic; Levodopa; Acoustic; Motor speech network; Caudate nucleus},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control},
   url = {http://www.sciencedirect.com/science/article/pii/S1353802015003818},
   volume = {22},
   year = {2016}
}

TY  - JOUR
ID  - 1321778
AU  - Elfmarková, Nela - Gajdoš, Martin - Mračková, Martina - Mekyska, Jiří - Mikl, Michal - Rektorová, Irena
PY  - 2016
TI  - Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 22
IS  - Supplement 1
SP  - "S52"-"S55"
EP  - "S52"-"S55"
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Parkinson's disease
KW  - Functional connectivity
KW  - Speech prosody
KW  - fMRI
KW  - Resting state
KW  - Dopaminergic
KW  - Levodopa
KW  - Acoustic
KW  - Motor speech network
KW  - Caudate nucleus
UR  - http://www.sciencedirect.com/science/article/pii/S1353802015003818
L2  - http://www.sciencedirect.com/science/article/pii/S1353802015003818
N2  - Background: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. Methods: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. Results: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody. Conclusions: We demonstrated an impact of PD but not of levodopa on rs-FC within the brain networks related to speech prosody control. When only the PD patients were taken into account, the association between treatment-induced changes in speech prosody and changes in rs-FC within the associative striato-prefrontal and motor speech networks was found. (C) 2015 Elsevier Ltd. All rights reserved.
ER  -

ELFMARKOVÁ, Nela, Martin GAJDOŠ, Martina MRAČKOVÁ, Jiří MEKYSKA, Michal MIKL a Irena REKTOROVÁ. Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2016, roč.~22, Supplement 1, s.~''S52''-''S55'', 4 s. ISSN~1353-8020. Dostupné z: https://dx.doi.org/10.1016/j.parkreldis.2015.09.006.

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