Hippocampal proton MR spectroscopy as a novel approach in the
assessment of radiation injury and the correlation to
neurocognitive function impairment: initial experiences

J 2015

Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences

POSPÍŠIL, Petr, Tomáš KAZDA, Martin BULIK, Marie DOBIÁŠKOVÁ, Petr BURKOŇ et. al.

Basic information

Original name

Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences

Authors

POSPÍŠIL, Petr (203 Czech Republic, guarantor, belonging to the institution), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Martin BULIK (203 Czech Republic, belonging to the institution), Marie DOBIÁŠKOVÁ (203 Czech Republic), Petr BURKOŇ (203 Czech Republic, belonging to the institution), Ludmila HYNKOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution) and Radim JANČÁLEK (203 Czech Republic, belonging to the institution)

Edition

Radiation Oncology, London, BioMed Central, 2015, 1748-717X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.466

RIV identification code

RIV/00216224:14110/15:00085324

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s13014-015-0518-1

UT WoS

000362871700001

Keywords in English

Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy

Abstract

V originále

Background: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by H-1-MR spectroscopy focused on the hippocampus. Methods: Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy H-1-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Results: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. Conclusions: A significant decrease in h-tNAA after WBRT was proven by H-1-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed.

Citovat

POSPÍŠIL, Petr, Tomáš KAZDA, Martin BULIK, Marie DOBIÁŠKOVÁ, Petr BURKOŇ, Ludmila HYNKOVÁ, Pavel ŠLAMPA and Radim JANČÁLEK. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. Radiation Oncology. London: BioMed Central, 2015, vol. 10, No 211, p. 1-8. ISSN 1748-717X. Available from: https://dx.doi.org/10.1186/s13014-015-0518-1.

@article{1321781,
   author = {Pospíšil, Petr and Kazda, Tomáš and Bulik, Martin and Dobiášková, Marie and Burkoň, Petr and Hynková, Ludmila and Šlampa, Pavel and Jančálek, Radim},
   article_location = {London},
   article_number = {211},
   doi = {http://dx.doi.org/10.1186/s13014-015-0518-1},
   keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
   language = {eng},
   issn = {1748-717X},
   journal = {Radiation Oncology},
   title = {Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences},
   volume = {10},
   year = {2015}
}

TY  - JOUR
ID  - 1321781
AU  - Pospíšil, Petr - Kazda, Tomáš - Bulik, Martin - Dobiášková, Marie - Burkoň, Petr - Hynková, Ludmila - Šlampa, Pavel - Jančálek, Radim
PY  - 2015
TI  - Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences
JF  - Radiation Oncology
VL  - 10
IS  - 211
SP  - 1-8
EP  - 1-8
PB  - BioMed Central
SN  - 1748717X
KW  - Hippocampus
KW  - Radiation injury
KW  - Neurocognitive function
KW  - Magnetic resonance spectroscopy
N2  - Background: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation of memory change to hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, by H-1-MR spectroscopy focused on the hippocampus. Methods: Patients with brain metastases underwent whole brain radiotherapy (WBRT) to a dose of 30 Gy in ten fractions daily. Pre-radiotherapy H-1-MR spectroscopy focused on the h-tNAA concentration and memory testing was performed. Memory was evaluated by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R). Total recall, recognition and delayed recall were reported. The both investigation procedures were repeated 4 months after WBRT and the h-tNAA and memory changes were correlated. Results: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4 after WBRT, respectively. In the memory tests a significant decrease was observed in AVLT total-recall, BVMT-R total-recall and BVMT-R delayed-recall. Weak to moderate correlations were observed between left h-tNAA and AVLT recognition and all BVMT-R subtests and between the right h-tNAA and AVLT total-recall. Conclusions: A significant decrease in h-tNAA after WBRT was proven by H-1-MR spectroscopy as a feasible method for the in vivo investigation of radiation injury. Continuing patient recruitment focusing on other cognitive tests and metabolites is needed.
ER  -

POSPÍŠIL, Petr, Tomáš KAZDA, Martin BULIK, Marie DOBIÁŠKOVÁ, Petr BURKOŇ, Ludmila HYNKOVÁ, Pavel ŠLAMPA and Radim JANČÁLEK. Hippocampal proton MR spectroscopy as a novel approach in the assessment of radiation injury and the correlation to neurocognitive function impairment: initial experiences. \textit{Radiation Oncology}. London: BioMed Central, 2015, vol.~10, No~211, p.~1-8. ISSN~1748-717X. Available from: https://dx.doi.org/10.1186/s13014-015-0518-1.

Detailed Information on Publication Record