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@article{1322192,
author = {Souček, Filip and Covassin, Naima and Singh, Prachi and Růžek, Lukáš and Kára, Tomáš and Suleiman, Mahmoud and Lerman, Amir and Koestler, Celeste and Friedman, Paul A. and LopezandJimenez, Francisco and Somers, Virend K.},
article_location = {Bridgewater},
article_number = {9},
doi = {http://dx.doi.org/10.1016/j.amjcard.2015.07.067},
keywords = {CARDIOVASCULAR RISK; STATINS; HEART; DIFFERENTIATION; METAANALYSIS; CHOLESTEROL; 3T3-L1; TRIALS; CELLS; FAT},
language = {eng},
issn = {0002-9149},
journal = {American Journal of Cardiology},
title = {Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation},
volume = {116},
year = {2015}
}
TY - JOUR
ID - 1322192
AU - Souček, Filip - Covassin, Naima - Singh, Prachi - Růžek, Lukáš - Kára, Tomáš - Suleiman, Mahmoud - Lerman, Amir - Koestler, Celeste - Friedman, Paul A. - Lopez-Jimenez, Francisco - Somers, Virend K.
PY - 2015
TI - Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation
JF - American Journal of Cardiology
VL - 116
IS - 9
SP - 1443-1446
EP - 1443-1446
PB - Excerpta Medica INC-Elsevier Science INC
SN - 00029149
KW - CARDIOVASCULAR RISK
KW - STATINS
KW - HEART
KW - DIFFERENTIATION
KW - METAANALYSIS
KW - CHOLESTEROL
KW - 3T3-L1
KW - TRIALS
KW - CELLS
KW - FAT
N2 - Epicardial adipose tissue (EAT) has been recognized as a sensitive marker of cardiometabolic risk. Recent evidence suggests efficacy of long-term statin therapy in reducing EAT in patients with coronary artery disease. Whether short-term statin therapy is associated with changes in the volume of EAT is currently unknown. A cohort of patients with atrial fibrillation who underwent pulmonary vein isolation were randomized to receive either 80 mg/day of atorvastatin (n = 38, 32 men, age 56 11 years) or placebo (n = 41, 33 men, age 56 +/- 10 years) for a 3-month period. EAT volume was assessed by cardiac computed tomography at baseline and at follow-up. Patients randomized to statin treatment exhibited a modest but significant decrease in median EAT volume (baseline vs follow-up: 92.3 cm(3) [62.0 to 133.3] vs 86.9 cm(3) [64.1 to 124.8], p < 0.05), whereas median EAT remained unchanged in the placebo group (81.9 cm(3) [55.5 to 110.9] vs 81.3 cm(3) [57.1 to 110.5], p = NS). Changes in median systemic inflammatory markers and lipid profile were also seen with statin treatment: C-reactive protein (2.4 mg/L [0.7 to 3.7] vs 1.1 mg/L [0.5 to 2.7], p < 0.05), total cholesterol (186 mg/dL [162.5 to 201] vs 123 mg/dL [99 to 162.5], p < 0.001), and low-density lipoprotein cholesterol (116 mg/dL [96.5 to 132.5] Vs 56 [40.5 to 81] mg/dL, p < 0.001) diminished, whereas median body mass index did not change (27.8 kg/m(2) [25 to 30] versus 27.6 kg/m(2) [25.7 to 30.5], p = NS). No variations occurred in the placebo group. In conclusion, short-term intensive statin therapy significantly reduced the volume of EAT in patients with atrial fibrillation. (C) 2015 Elsevier Inc. All rights reserved.
ER -
SOUČEK, Filip, Naima COVASSIN, Prachi SINGH, Lukáš RŮŽEK, Tomáš KÁRA, Mahmoud SULEIMAN, Amir LERMAN, Celeste KOESTLER, Paul A. FRIEDMAN, Francisco LOPEZ-JIMENEZ a Virend K. SOMERS. Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation. \textit{American Journal of Cardiology}. Bridgewater: Excerpta Medica INC-Elsevier Science INC, 2015, roč.~116, č.~9, s.~1443-1446. ISSN~0002-9149. Dostupné z: https://dx.doi.org/10.1016/j.amjcard.2015.07.067.
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