Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

PALEČEK, Jan and Stephan GRUBER. Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes. Structure. CAMBRIDGE: CELL PRESS, 2015, vol. 23, No 12, p. 2183-2190. ISSN 0969-2126. Available from: https://dx.doi.org/10.1016/j.str.2015.10.004.

Basic information

• Original name: Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes
• Name in Czech: KITE proteiny: Superrodina SMC/kleisin partnerů konzervovaná v bakteriích, archea a eukaryotech
• Authors: PALEČEK, Jan (203 Czech Republic, guarantor, belonging to the institution) and Stephan GRUBER (276 Germany).
• Edition: Structure, CAMBRIDGE, CELL PRESS, 2015, 0969-2126.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10600 1.6 Biological sciences
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 5.237
• RIV identification code: RIV/00216224:14740/15:00081379
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1016/j.str.2015.10.004
• UT WoS: 000366171500001
• Keywords in English: SMC structural maintenance of chromosomes; Cohesin; Condensin; Smc5/6; MukBEF; MksBEF; MAGE; Smc/ScpAB; kleisin; chromosome segregation; cohesion; condensation; replication; winged helix domains; kite proteins
• Tags: MAGE proteins, rivok, SMC5-6 complex
• Tags: International impact, Reviewed

Abstract

SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as "kite'' proteins for kleisin interacting tandem winged-helix (WH) elements of SMC complexes). Kite proteins are integral parts of all prokaryotic SMC complexes and Smc5/6 but not cohesin and condensin. They are made up of tandem WH domains, form homo-or heterodimers via their amino-terminal WH domain, and they associate with the central part of a kleisin subunit. In placental mammals, the kite subunit NSE3 gave rise to several (>60) kite-related proteins, named MAGE, many of which encode tumor-and testis-specific antigens. Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6.

Links

• ED1.1.00/02.0068, research and development project: Name: CEITEC - central european institute of technology
• GA13-00774S, research and development project: Name: Úloha proteinů Nse, podjednotek komplexu SMC5/6, v procesech stabilizujících pozastavené replikační vidlice

Investor: Czech Science Foundation