Early MRD response as a prognostic factor in adult patients
with acute lymphoblastic leukemia

J 2016

Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia

ŠÁLEK, Cyril, František FOLBER, Eva FROŇKOVÁ, Bohumír PROCHÁZKA, Iuri MARINOV et. al.

Základní údaje

Originální název

Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia

Autoři

ŠÁLEK, Cyril (203 Česká republika), František FOLBER (203 Česká republika, garant, domácí), Eva FROŇKOVÁ (203 Česká republika), Bohumír PROCHÁZKA (203 Česká republika), Iuri MARINOV (203 Česká republika), Petr CETKOVSKÝ (203 Česká republika), Jiří MAYER (203 Česká republika, domácí) a Michael DOUBEK (203 Česká republika, domácí)

Vydání

European Journal of Haematology, Hoboken, Wiley-Blackwell, 2016, 0902-4441

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.653

Kód RIV

RIV/00216224:14110/16:00089256

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/ejh.12587

UT WoS

000370346800009

Klíčová slova anglicky

acute lymphoblastic leukemia; minimal residual disease; prognostic factors; early response; BCR-ABL; immunoglobulin and T-cell receptor gene rearrangements

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 8. 2016 14:31, Ing. Mgr. Věra Pospíšilíková

Anotace

V originále

Objective To evaluate the prognostic power of minimal residual disease (MRD) monitored by polymerase chain reaction at defined time points during early treatment in adult patients with acute lymphoblastic leukemia (ALL). Methods Seventy-one patients were treated according to the GMALL 07/2003 protocol and evaluated for MRD in bone marrow by specific clonal rearrangements of Ig/TCR in BCR-ABL negative ALL or fusion gene transcript in BCR-ABL positive ALL. Results Three-year overall survival (OS) was 94% in patients with BCR-ABL negative ALL reaching complete molecular response (CMR) after the first course of chemotherapy (vs. 32% if MRD >10(-4); P=0.001). Patients with CMR prior to the start of consolidation chemotherapy at week 11 had 3-yr OS 82% (vs. 18% if MRD >10(-4); P=0.001). Patients with BCR-ABL positive ALL showed slower MRD dynamics. There was a trend to better OS in patients with 4 log reduction of BCR-ABL transcript prior to HSCT (92% vs. 50%; P=0.065). None of the patients with detectable MRD (both BCR-ABL positive and negative) after HSCT survived 3yr. Conclusion Early MRD kinetics is an important tool for new prognostication models with direct clinical impact irrespective of standard prognostic factors in patients with BCR-ABL negative ALL.

Návaznosti

ED1.1.00/02.0068, projekt VaV

Název: CEITEC - central european institute of technology

Citovat

ŠÁLEK, Cyril, František FOLBER, Eva FROŇKOVÁ, Bohumír PROCHÁZKA, Iuri MARINOV, Petr CETKOVSKÝ, Jiří MAYER a Michael DOUBEK. Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia. European Journal of Haematology. Hoboken: Wiley-Blackwell, 2016, roč. 96, č. 3, s. 276-284. ISSN 0902-4441. Dostupné z: https://dx.doi.org/10.1111/ejh.12587.

@article{1324097,
   author = {Šálek, Cyril and Folber, František and Froňková, Eva and Procházka, Bohumír and Marinov, Iuri and Cetkovský, Petr and Mayer, Jiří and Doubek, Michael},
   article_location = {Hoboken},
   article_number = {3},
   doi = {http://dx.doi.org/10.1111/ejh.12587},
   keywords = {acute lymphoblastic leukemia; minimal residual disease; prognostic factors; early response; BCR-ABL; immunoglobulin and T-cell receptor gene rearrangements},
   language = {eng},
   issn = {0902-4441},
   journal = {European Journal of Haematology},
   title = {Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia},
   volume = {96},
   year = {2016}
}

TY  - JOUR
ID  - 1324097
AU  - Šálek, Cyril - Folber, František - Froňková, Eva - Procházka, Bohumír - Marinov, Iuri - Cetkovský, Petr - Mayer, Jiří - Doubek, Michael
PY  - 2016
TI  - Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia
JF  - European Journal of Haematology
VL  - 96
IS  - 3
SP  - 276-284
EP  - 276-284
PB  - Wiley-Blackwell
SN  - 09024441
KW  - acute lymphoblastic leukemia
KW  - minimal residual disease
KW  - prognostic factors
KW  - early response
KW  - BCR-ABL
KW  - immunoglobulin and T-cell receptor gene rearrangements
N2  - Objective To evaluate the prognostic power of minimal residual disease (MRD) monitored by polymerase chain reaction at defined time points during early treatment in adult patients with acute lymphoblastic leukemia (ALL). Methods Seventy-one patients were treated according to the GMALL 07/2003 protocol and evaluated for MRD in bone marrow by specific clonal rearrangements of Ig/TCR in BCR-ABL negative ALL or fusion gene transcript in BCR-ABL positive ALL. Results Three-year overall survival (OS) was 94% in patients with BCR-ABL negative ALL reaching complete molecular response (CMR) after the first course of chemotherapy (vs. 32% if MRD >10(-4); P=0.001). Patients with CMR prior to the start of consolidation chemotherapy at week 11 had 3-yr OS 82% (vs. 18% if MRD >10(-4); P=0.001). Patients with BCR-ABL positive ALL showed slower MRD dynamics. There was a trend to better OS in patients with 4 log reduction of BCR-ABL transcript prior to HSCT (92% vs. 50%; P=0.065). None of the patients with detectable MRD (both BCR-ABL positive and negative) after HSCT survived 3yr. Conclusion Early MRD kinetics is an important tool for new prognostication models with direct clinical impact irrespective of standard prognostic factors in patients with BCR-ABL negative ALL.
ER  -

ŠÁLEK, Cyril, František FOLBER, Eva FROŇKOVÁ, Bohumír PROCHÁZKA, Iuri MARINOV, Petr CETKOVSKÝ, Jiří MAYER a Michael DOUBEK. Early MRD response as a prognostic factor in adult patients with acute lymphoblastic leukemia. \textit{European Journal of Haematology}. Hoboken: Wiley-Blackwell, 2016, roč.~96, č.~3, s.~276-284. ISSN~0902-4441. Dostupné z: https://dx.doi.org/10.1111/ejh.12587.

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