J 2016

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

RÁJOVÁ, Jana, Roman PANTŮČEK, Petr PETRÁŠ, Ivana VARBANOVOVÁ, Ivana MAŠLAŇOVÁ et. al.

Basic information

Original name

Necrotizing pneumonia due to clonally diverse Staphylococcus aureus strains producing Panton-Valentine leukocidin: the Czech experience

Authors

RÁJOVÁ, Jana (203 Czech Republic, belonging to the institution), Roman PANTŮČEK (203 Czech Republic, guarantor, belonging to the institution), Petr PETRÁŠ (203 Czech Republic), Ivana VARBANOVOVÁ (203 Czech Republic), Ivana MAŠLAŇOVÁ (203 Czech Republic, belonging to the institution) and Jiří BENEŠ (203 Czech Republic)

Edition

Epidemiology & Infection, Cambridge University Press, 2016, 0950-2688

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10600 1.6 Biological sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 2.075

RIV identification code

RIV/00216224:14310/16:00087773

Organization unit

Faculty of Science

DOI

UT WoS

000368636200006

Keywords in English

Community-acquired pneumonia; necrotizing pneumonia; Panton–Valentine leukocidin; septic shock; Staphylococcus aureus

Tags

Tags

International impact, Reviewed
Změněno: 26/10/2020 10:44, prof. RNDr. Roman Pantůček, Ph.D.

Abstract

V originále

A prospective study (2007–2013) was undertaken to investigate clinical features and prognostic factors of necrotizing pneumonia caused by Staphylococcus aureus producing Panton–Valentine leukocidin (PVL) in the Czech Republic. Twelve cases of necrotizing pneumonia were detected in 12 patients (median age 25 years) without severe underlying disease. Eight cases occurred in December and January and the accumulation of cases in the winter months preceding the influenza season was statistically significant (P < 0·001). The course of pneumonia was very rapid, leading to early sepsis and/or septic shock in all but one patient. Seven patients died and mortality was fourfold higher in those patients presenting with primary pneumonia than with pneumonia complicating other staphylococcal/pyogenic infection elsewhere in the body. The S. aureus isolates displayed considerable genetic variability and were assigned to five lineages CC8 (n = 3), CC15 (n = 2), CC30 (n = 2), CC80 (n = 1), and CC121 (n = 3) and one was a singleton of ST154 (n = 1), all were reported to be associated with community-acquired infection. Four strains were methicillin resistant. The high case-fatality rate can only be reduced by improving the speed of diagnosis and a rapid test to detect S. aureus in the airways is needed.

Links

GP13-05069P, research and development project
Name: Horizontální přenos stafylokokové chromozomové kazety mec (SCCmec) prostřednictvím bakteriofágů napříč kmeny rodu Staphylococcus
Investor: Czech Science Foundation
NT12395, research and development project
Name: Molekulární průkaz a analýza invazivních kmenů small colony variants (SCV) a rezistentních kmenů S. aureus od pacientů s cystickou fibrózou

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