a 2015

Alcohol intoxication, arrhythmias and inward rectifiers

BÉBAROVÁ, Markéta

Základní údaje

Originální název

Alcohol intoxication, arrhythmias and inward rectifiers

Autoři

Vydání

4th Global Summit on Toxicology, 2015

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30105 Physiology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Organizační jednotka

Lékařská fakulta

ISSN

Klíčová slova česky

alkohol; arytmie; fibrilace síní; inward rectifier

Klíčová slova anglicky

alcohol; arrhythmias; atrial fibrillation; inward rectifier

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 25. 1. 2016 13:53, doc. MUDr. Markéta Bébarová, Ph.D.

Anotace

V originále

Alcohol intoxication may induce electrocardiographic changes and arrhythmias, most frequently the atrial fibrillation (AF). In the pathogenesis of arrhythmias including AF, modifications and/or heterogeneity of inward rectifier potassium currents, namely IK1 and acetylcholine-sensitive current IK(Ach), are known to be involved. Recently, we have reported that ethanol at clinically relevant concentrations alters the rat ventricular IK1 in a dual way. We have also observed a significant inhibitory effect of acetaldehyde, the primary metabolite of ethanol, on this current. Considering missing data, we aimed to analyze ethanol-induced changes of inward rectifiers in the cardiac atria. Experiments were performed by the whole-cell patch clamp technique at room temperature in enzymatically isolated rat atrial myocytes. In contrast to the ventricular IK1, ethanol in concentrations of 20 and 80 mM (0.09 and 0.4%) showed only minor average changes of the atrial IK1. In the case of IK(Ach), both components of this current, i.e. the constitutively active and the acetylcholine-induced IK(Ach), were affected by ethanol. The constitutively active IK(Ach) was significantly increased at all examined concentrations between 2 and 80 mM (e.g. at 20 mM by 114.6±28.3%). The acetylcholine-induced IK(Ach) was affected by 8 to 80 mM ethanol in a dual way with its prevailing activation (e.g. by 29.2±17.3% at 20 mM). To conclude, the effect of ethanol on the atrial IK1 was minor compared to its effect on the ventricular IK1. Changes of the atrial electrophysiology under alcohol intoxication are likely caused by other factors, the clinically relevant action of ethanol on IK(Ach) may contribute.

Návaznosti

NT14301, projekt VaV
Název: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?
Investor: Ministerstvo zdravotnictví ČR, Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?