| ŠERÝ, Omar, Ivo PACLT, Ivana DRTÍLKOVÁ, Pavel THEINER, Marta KOPECKOVA, Petr ZVOLSKÝ and Vladimír BALCAR. A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism. Behavioral and Brain Functions. London: BIOMED CENTRAL LTD, vol. 11, JUNE, p. "nestrankovano", 8 pp. ISSN 1744-9081. doi:10.1186/s12993-015-0066-8. 2015. |
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@article{1332569,
author = {Šerý, Omar and Paclt, Ivo and Drtílková, Ivana and Theiner, Pavel and Kopeckova, Marta and Zvolský, Petr and Balcar, Vladimír},
article_location = {London},
article_number = {JUNE},
doi = {http://dx.doi.org/10.1186/s12993-015-0066-8},
keywords = {Hyperkinetic disorder; Polymorphism; Alcoholism; Dopamine transporter; miRNA},
language = {eng},
issn = {1744-9081},
journal = {Behavioral and Brain Functions},
title = {A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism},
volume = {11},
year = {2015}
}
TY - JOUR
ID - 1332569
AU - Šerý, Omar - Paclt, Ivo - Drtílková, Ivana - Theiner, Pavel - Kopeckova, Marta - Zvolský, Petr - Balcar, Vladimír
PY - 2015
TI - A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism
JF - Behavioral and Brain Functions
VL - 11
IS - JUNE
SP - "nestrankovano"
EP - "nestrankovano"
PB - BIOMED CENTRAL LTD
SN - 17449081
KW - Hyperkinetic disorder
KW - Polymorphism
KW - Alcoholism
KW - Dopamine transporter
KW - miRNA
N2 - Background: ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission. Methods: A total of 1312 subjects were included and genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls, 218 ADHD children and 253 non ADHD children). Using miRBase software, we have performed a computer analysis of VNTR part of DAT1 gene for presence of miRNA binding sites. Results: We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P < 0.01). The 9/9 genotype appeared to reduce the risk of ADHD about 0.4-fold (p < 0.04). We also noted an occurrence of rare genotypes in ADHD (frequency different from controls at p < 0.01). No association between alcoholism and genotype frequencies of 40 bp VNTR polymorphism of DAT1/SLC6A3 gene has been detected. Conclusions: We have found an association between 40 bp VNTR polymorphism of DAT1/SLC6A3 gene and ADHD in the Czech population; in a broad agreement with studies in other population samples. Furthermore, we detected rare genotypes 8/10, 7/10 and 10/11 present in ADHD boys only and identified miRNAs that should be looked at as potential novel targets in the research on ADHD.
ER -
ŠERÝ, Omar, Ivo PACLT, Ivana DRTÍLKOVÁ, Pavel THEINER, Marta KOPECKOVA, Petr ZVOLSKÝ and Vladimír BALCAR. A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism. \textit{Behavioral and Brain Functions}. London: BIOMED CENTRAL LTD, vol.~11, JUNE, p.~''nestrankovano'', 8 pp. ISSN~1744-9081. doi:10.1186/s12993-015-0066-8. 2015.
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