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@inproceedings{1332579,
author = {Zeman, Tomáš and Buchtová, marcela and Dočekal, Bohumil and Míšek, Ivan and Navrátil, Josef and Mikuška, Pavel and Šerý, Omar and Večeřa, Zbyněk},
address = {BRISTOL},
booktitle = {4TH INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS (NANOSAFE2014)},
doi = {http://dx.doi.org/10.1088/1742-6596/617/1/012018},
keywords = {nanoparticle; nantechnology; model; inhalation},
howpublished = {tištěná verze "print"},
language = {eng},
location = {BRISTOL},
note = {Žádný z autorů nemá na WoS afiliaci na MU, nelze tedy výsledek přenášet do RIV!},
pages = {1-6},
publisher = {IOP PUBLISHING LTD},
title = {Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles},
url = {https://iopscience.iop.org/article/10.1088/1742-6596/617/1/012018/pdf},
year = {2015}
}
TY - JOUR
ID - 1332579
AU - Zeman, Tomáš - Buchtová, marcela - Dočekal, Bohumil - Míšek, Ivan - Navrátil, Josef - Mikuška, Pavel - Šerý, Omar - Večeřa, Zbyněk
PY - 2015
TI - Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles
PB - IOP PUBLISHING LTD
CY - BRISTOL
N1 - Žádný z autorů nemá na WoS afiliaci na MU, nelze tedy výsledek přenášet do RIV!
KW - nanoparticle
KW - nantechnology
KW - model
KW - inhalation
UR - https://iopscience.iop.org/article/10.1088/1742-6596/617/1/012018/pdf
N2 - Recently, it has been proven that manganese from inhaled particles of manganese compounds can accumulate in the internal organs of laboratory animals. Nevertheless, there were only a few researches dealing with changes in body morphology induced by inhalation of these particles, even though results of some studies indicate existence of such changes. The aim of our research was to assess the effect of inhaled manganese oxides nanoparticles on weight of internal organs. For this purpose a long-term inhalation experiment on laboratory mice was performed, during which the mice were exposed to MnO. Mn2O3 nanoparticles in concentration 2 x 10(6) particles/cm(3) for 17 weeks, 24 hours a day, 7 days a week. Manganese oxides nanoparticles were synthesized continuously via aerosol route in a hot wall tube flow reactor using thermal decomposition of metal organic precursor manganese(II) acetylacetonate in the flow tube reactor at temperature 750 degrees C in the presence of 30 vol% of oxygen. It was proven that inhaled nanoparticles can influence the weight of internal organs of mice. Moreover, it was discovered that the resulting change in weight of selected organs is disproportional. The mice from the experimental group had statistically significantly lighter kidneys, liver and spleen and heavier pancreas compared to the mice from the control group.
ER -
ZEMAN, Tomáš, marcela BUCHTOVÁ, Bohumil DOČEKAL, Ivan MÍŠEK, Josef NAVRÁTIL, Pavel MIKUŠKA, Omar ŠERÝ and Zbyněk VEČEŘA. Organ weight changes in mice after long-term inhalation exposure to manganese oxides nanoparticles. In \textit{4TH INTERNATIONAL CONFERENCE ON SAFE PRODUCTION AND USE OF NANOMATERIALS (NANOSAFE2014)}. BRISTOL: IOP PUBLISHING LTD, 2015, p.~1-6. ISSN~1742-6588. Available from: https://dx.doi.org/10.1088/1742-6596/617/1/012018.
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