Chronobiology of acute cardiovascular events.

LIPKOVÁ, Jolana, Jiří PAŘENICA, Jaroslav SVOBODA, Simona LITTNEROVÁ, Jindřich ŠPINAR, Anna VAŠKŮ and Monika PÁVKOVÁ GOLDBERGOVÁ. Chronobiology of acute cardiovascular events. In CEITEC PhD Retreat 2015. 2015. ISBN 978-80-210-7825-3.

Basic information

Original name

Chronobiology of acute cardiovascular events.

Name in Czech

Chronobiologie akutních kardiovaskulárních příhod.

Name (in English)

Chronobiology of acute cardiovascular events.

Authors

LIPKOVÁ, Jolana, Jiří PAŘENICA, Jaroslav SVOBODA, Simona LITTNEROVÁ, Jindřich ŠPINAR, Anna VAŠKŮ and Monika PÁVKOVÁ GOLDBERGOVÁ

Edition

CEITEC PhD Retreat 2015, 2015

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Other information

Type of outcome

Konferenční abstrakt

Confidentiality degree

není předmětem státního či obchodního tajemství

ISBN

978-80-210-7825-3

Keywords (in Czech)

chronobiologie, kardiologie, Clock geny

Keywords in English

chronobiology, cardiology, Clock genes

Tags

International impact

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Abstract

V originále

Incidence of acute cardiovascular diseases show chronobiological variations, althought little is known about its influence on further prognosis and mortality. Circadian rhythms are genetically determined and variations at the molecular level can modulate the response to external/internal stumuli affecting thus fenotype of the disease. In our research we investigated circadian pattern of time of onset in acute myocardial infarction and acute heart failure and its influence on clinical parametres of the disease. Further we focues on effect of chronotype (determined by functional polymorphism VNTR in Period3 gene) on basic parametres of myocardial infarction. Rhythmicity of clinical data and biochemical factors was investigated by using partial Fourier analysis and patients with AMI were genotyped for Per3 VNTR polymorphism using an allele-specific PCR.