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@article{1333713,
author = {Sándor, Roman and Midlik, Adam and Šebrlová, Kristýna and Dovrtělová, Gabriela and Nosková, Kristýna and Juřica, Jan and Slaninová, Iva and Táborská, Eva and Peš, Ondřej},
article_location = {Amsterdam},
article_number = {"neuvedeno"},
doi = {http://dx.doi.org/10.1016/j.jpba.2016.01.024},
keywords = {benzophenanthridines; metabolites; rat liver microsomes; mass spectrometry; isolation},
language = {eng},
issn = {0731-7085},
journal = {Journal of Pharmaceutical and Biomedical Analysis},
title = {Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation},
url = {http://www.sciencedirect.com/science/article/pii/S0731708516300255},
volume = {121},
year = {2016}
}
TY - JOUR
ID - 1333713
AU - Sándor, Roman - Midlik, Adam - Šebrlová, Kristýna - Dovrtělová, Gabriela - Nosková, Kristýna - Juřica, Jan - Slaninová, Iva - Táborská, Eva - Peš, Ondřej
PY - 2016
TI - Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation
JF - Journal of Pharmaceutical and Biomedical Analysis
VL - 121
IS - "neuvedeno"
SP - 174-180
EP - 174-180
PB - Elsevier Science BV
SN - 07317085
KW - benzophenanthridines
KW - metabolites
KW - rat liver microsomes
KW - mass spectrometry
KW - isolation
UR - http://www.sciencedirect.com/science/article/pii/S0731708516300255
N2 - Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown. Reactions involved in transformation include single and/or double O-demethylation, demethylenation, reduction, and hydroxylation. Two metabolites, when isolated, purified and tested for toxicity, were found to be less toxic than the original compounds.
ER -
SÁNDOR, Roman, Adam MIDLIK, Kristýna ŠEBRLOVÁ, Gabriela DOVRTĚLOVÁ, Kristýna NOSKOVÁ, Jan JUŘICA, Iva SLANINOVÁ, Eva TÁBORSKÁ a Ondřej PEŠ. Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation. \textit{Journal of Pharmaceutical and Biomedical Analysis}. Amsterdam: Elsevier Science BV, 2016, roč.~121, ''neuvedeno'', s.~174-180. ISSN~0731-7085. Dostupné z: https://dx.doi.org/10.1016/j.jpba.2016.01.024.
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