2015
Phytoestrogens and mycoestrogens in surface waters - Their sources, occurrence, and potential contribution to estrogenic activity
JAVŮRKOVÁ, Barbora, Jakub JAVŮREK, Ondřej ADAMOVSKÝ a Klára HILSCHEROVÁZákladní údaje
Originální název
Phytoestrogens and mycoestrogens in surface waters - Their sources, occurrence, and potential contribution to estrogenic activity
Autoři
JAVŮRKOVÁ, Barbora (203 Česká republika, domácí), Jakub JAVŮREK (203 Česká republika, domácí), Ondřej ADAMOVSKÝ (203 Česká republika, domácí) a Klára HILSCHEROVÁ (203 Česká republika, garant, domácí)
Vydání
Environment International, OXFORD (ENGLAND), Pergamon Press, 2015, 0160-4120
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10511 Environmental sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 5.929
Kód RIV
RIV/00216224:14310/15:00081583
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000356748900004
Klíčová slova anglicky
Phytoestrogen; Mycoestrogen; Estrogenicity; Sterol; Phytosterols; Flavonoids; Surface waters; Estrogenic equivalent; Relative potency
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 8. 4. 2016 09:59, Ing. Andrea Mikešková
Anotace
V originále
This review discusses the potential contribution of phytoestrogens and mycoestrogens to in vitro estrogenic activities occurring in surface waters and in vivo estrogenic effects in fish. Main types, sources, and pathways of entry into aquatic environment of these detected compounds were summarized. Reviewed concentrations of phyto/mycoestrogens in surface waters were mostly undetectable or in low ng/L ranges, but exceeded tens of mu g/L for the flavonoids biochanin A, daidzein and genistein at some sites. While a few phytosterols were reported to occur at relatively high concentrations in surface waters, information about their potencies in in vitro systems is very limited, and contradictory in some cases. The relative estrogenic activities of compounds (compared to standard estrogen 17 beta-estradiol) by various in vitro assays were included, and found to differ by orders of magnitude. These potencies were used to estimate total potential estrogenic activities based on chemical analyses of phyto/mycoestrogens. In vivo effective concentrations of waterborne phyto/mycoestrogens were available only for biochanin A, daidzein, formononetin, genistein, equol, sitosterol, and zearalenone. The lowest observable effect concentrations in vivo were reported for the mycoestrogen zearalenone. This compound and especially its metabolites also elicited the highest in vitro estrogenic potencies. Despite the limited information available, the review documents low contribution of phyto/mycoestrogens to estrogenic activity in vast majority of surface waters, but significant contribution to in vitro responses and potentially also to in vivo effects in areas with high concentrations.
Návaznosti
GAP503/12/0553, projekt VaV |
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