2015
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
ADAMOVSKÝ, Ondřej, Zdena MOOSOVÁ, Michaela PEKAROVA, Amrita BASU, Pavel BABICA et. al.Základní údaje
Originální název
Immunomodulatory Potency of Microcystin, an Important Water-Polluting Cyanobacterial Toxin
Autoři
ADAMOVSKÝ, Ondřej (203 Česká republika, garant, domácí), Zdena MOOSOVÁ (203 Česká republika, domácí), Michaela PEKAROVA (203 Česká republika), Amrita BASU (356 Indie, domácí), Pavel BABICA (203 Česká republika, domácí), Lenka Svihalkova SINDLEROVA (203 Česká republika), Lukáš KUBALA (203 Česká republika) a Luděk BLÁHA (203 Česká republika, domácí)
Vydání
Environmental Science and Technology, WASHINGTON, DC (USA), American Chemical Society, 2015, 0013-936X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10511 Environmental sciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Odkazy
Impakt faktor
Impact factor: 5.393
Kód RIV
RIV/00216224:14310/15:00081602
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000363348700054
Klíčová slova anglicky
NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS; ANION TRANSPORTING POLYPEPTIDES; ACTIVATED PROTEIN-KINASE; MELANOMA-CELL INVASION; LIVER-TUMOR PROMOTION; NITRIC-OXIDE; SIGNALING PATHWAYS; IN-VITRO
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 14. 3. 2016 20:43, Mgr. Michaela Hylsová, Ph.D.
Anotace
V originále
Microcystins (MCs) are primarily hepatotoxins produced by cyanobacteria and are responsible for intoxication in humans and animals. There are many incidents of chronic exposure to MCs, which have been attributed to the inappropriate treatment of water supplies or contaminated food. Using RAW 264.7 macrophages, we showed the potency of microcystin-LR (MC-LR) to stimulate production of pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin-6) as a consequence of fast nuclear factor kappa B and nitrogen-activated protein kinase activation. In contrast to other studies, the observed effects were not attributed to the intracellular inhibition of protein phosphatases 1/2A due to lack of specific transmembrane transporters for MCs. However, the MC-LR-induced activation of macrophages was effectively inhibited by a specific peptide that blocks signaling of receptors, which play a pivotal role in the innate immune responses. Taken together, we showed for the first time that MC-LR could interfere with macrophage receptors that are responsible for triggering the above-mentioned signaling pathways. These findings provide an interesting mechanistic explanation of some adverse health outcomes associated with toxic cyanobacteria and MCs.
Návaznosti
GP13-27695P, projekt VaV |
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