Time-course pattern of blood 25-hydroxycholecalciferol is a
significant predictor of survival outcome in metastatic
colorectal cancer: a clinical practice-based study

J 2015

Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study

OBERMANNOVÁ, Radka, Ladislav DUŠEK, K. GREPLOVA, Jiří JARKOVSKÝ, Jaroslav ŠTĚRBA et. al.

Základní údaje

Originální název

Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study

Autoři

OBERMANNOVÁ, Radka (203 Česká republika, domácí), Ladislav DUŠEK (203 Česká republika, domácí), K. GREPLOVA (203 Česká republika), Jiří JARKOVSKÝ (203 Česká republika, domácí), Jaroslav ŠTĚRBA (203 Česká republika, domácí), Rostislav VYZULA (203 Česká republika, domácí), Regina DEMLOVÁ (203 Česká republika, domácí), Lenka ZDRAŽILOVÁ DUBSKÁ (203 Česká republika, domácí) a Dalibor VALÍK (203 Česká republika, garant, domácí)

Vydání

Neoplasma, BRATISLAVA, Slovenská akademie vied, 2015, 0028-2685

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30200 3.2 Clinical medicine

Stát vydavatele

Slovensko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.961

Kód RIV

RIV/00216224:14110/15:00086876

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.4149/neo_2015_116

UT WoS

000365931800015

Klíčová slova anglicky

colorectal cancer; vitamin D; outcome predictors

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 3. 2016 12:59, Soňa Böhmová

Anotace

V originále

Vitamin D deficiency has been implicated in the epidemiology of common malignancies including colorectal cancer. We studied consecutive blood levels of 25-hydroxycholecalciferol (25-OHD) in relation to other clinical and laboratory variables in metastatic colorectal cancer patients to ascertain whether their variations may be prognostic or predictive parameters of survival outcomes. Eighty four patients treated with first-line oxaliplatin-based chemotherapy with or without bevacizumab were included. The patients were enrolled on the intent-to-treat basis considering their performance status, comorbidities and laboratory parameters to be medically apt for intensive chemotherapy. Overall survival and progression-free survival were selected as the primary outcomes. Progression free survival and overall survival medians were 15.4 months and 41.2 months, respectively. The cut-off levels of 40 nmol/l for 25-OHD and 11 mu g/l for first CEA were identified to be clinical decision levels stratifying patients to the respective prognostic groups. We found that the most consistent outcome predictors were i) any patient surgery, ii) CEA and, independently, iii) time-related blood levels of 25-OHD. We confirmed fundamental and consistent vitamin D deficiency in metastatic colorectal cancer. We demonstrated that all patients with at least one blood level above 40 nmol/l versus all below this cut-off showed profound differences in their disease outcomes. The primary disease stage or time to metastatic stage did not influence the predictive power of blood 25-OHD levels, implying that the time-course pattern of 25-OHD but not the first single measurement may be an independent prognostic factor.

Návaznosti

LM2011017, projekt VaV

Název: Advanced Cell Immunotherapy Unit - ACIU

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Advanced cell immunotherapy unit BVI-ACIU

Citovat

OBERMANNOVÁ, Radka, Ladislav DUŠEK, K. GREPLOVA, Jiří JARKOVSKÝ, Jaroslav ŠTĚRBA, Rostislav VYZULA, Regina DEMLOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ a Dalibor VALÍK. Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study. Neoplasma. BRATISLAVA: Slovenská akademie vied, 2015, roč. 62, č. 6, s. 958-965. ISSN 0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo_2015_116.

@article{1338008,
   author = {Obermannová, Radka and Dušek, Ladislav and Greplova, K. and Jarkovský, Jiří and Štěrba, Jaroslav and Vyzula, Rostislav and Demlová, Regina and Zdražilová Dubská, Lenka and Valík, Dalibor},
   article_location = {BRATISLAVA},
   article_number = {6},
   doi = {http://dx.doi.org/10.4149/neo_2015_116},
   keywords = {colorectal cancer; vitamin D; outcome predictors},
   language = {eng},
   issn = {0028-2685},
   journal = {Neoplasma},
   title = {Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study},
   volume = {62},
   year = {2015}
}

TY  - JOUR
ID  - 1338008
AU  - Obermannová, Radka - Dušek, Ladislav - Greplova, K. - Jarkovský, Jiří - Štěrba, Jaroslav - Vyzula, Rostislav - Demlová, Regina - Zdražilová Dubská, Lenka - Valík, Dalibor
PY  - 2015
TI  - Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study
JF  - Neoplasma
VL  - 62
IS  - 6
SP  - 958-965
EP  - 958-965
PB  - Slovenská akademie vied
SN  - 00282685
KW  - colorectal cancer
KW  - vitamin D
KW  - outcome predictors
N2  - Vitamin D deficiency has been implicated in the epidemiology of common malignancies including colorectal cancer. We studied consecutive blood levels of 25-hydroxycholecalciferol (25-OHD) in relation to other clinical and laboratory variables in metastatic colorectal cancer patients to ascertain whether their variations may be prognostic or predictive parameters of survival outcomes. Eighty four patients treated with first-line oxaliplatin-based chemotherapy with or without bevacizumab were included. The patients were enrolled on the intent-to-treat basis considering their performance status, comorbidities and laboratory parameters to be medically apt for intensive chemotherapy. Overall survival and progression-free survival were selected as the primary outcomes. Progression free survival and overall survival medians were 15.4 months and 41.2 months, respectively. The cut-off levels of 40 nmol/l for 25-OHD and 11 mu g/l for first CEA were identified to be clinical decision levels stratifying patients to the respective prognostic groups. We found that the most consistent outcome predictors were i) any patient surgery, ii) CEA and, independently, iii) time-related blood levels of 25-OHD. We confirmed fundamental and consistent vitamin D deficiency in metastatic colorectal cancer. We demonstrated that all patients with at least one blood level above 40 nmol/l versus all below this cut-off showed profound differences in their disease outcomes. The primary disease stage or time to metastatic stage did not influence the predictive power of blood 25-OHD levels, implying that the time-course pattern of 25-OHD but not the first single measurement may be an independent prognostic factor.
ER  -

OBERMANNOVÁ, Radka, Ladislav DUŠEK, K. GREPLOVA, Jiří JARKOVSKÝ, Jaroslav ŠTĚRBA, Rostislav VYZULA, Regina DEMLOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ a Dalibor VALÍK. Time-course pattern of blood 25-hydroxycholecalciferol is a significant predictor of survival outcome in metastatic colorectal cancer: a clinical practice-based study. \textit{Neoplasma}. BRATISLAVA: Slovenská akademie vied, 2015, roč.~62, č.~6, s.~958-965. ISSN~0028-2685. Dostupné z: https://dx.doi.org/10.4149/neo\_{}2015\_{}116.

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