Is Mild Cognitive Impairment a Precursor of Alzheimer's
Disease? Short Review

J 2015

Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review

JANOUTOVÁ, Jana, Omar ŠERÝ, Ladislav HOSÁK and Vladimír JANOUT

Basic information

Original name

Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review

Authors

JANOUTOVÁ, Jana, Omar ŠERÝ, Ladislav HOSÁK and Vladimír JANOUT

Edition

Central European Journal of Public Health, Tigis s.r.o. 2015, 1210-7778

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.525

Organization unit

Faculty of Science

UT WoS

000370311200014

Keywords in English

mild cognitive impairment; Alzheimer’s dementia; terminology; genetics; neuropsychological testing; secondary prevention

Abstract

V originále

Mild Cognitive Impairment (MCI) may be a precursor of Alzheimer's disease (AD). There is a boundary area between normal aging and dementia. In practice, the term "age related cognitive decline" has been used interchangeably with "normal aging". Alternatively, the term "aging associated cognitive decline" was introduced and defined by a performance on a standardized cognitive scale focused on learning and memory, attention and cognitive speed, language, or visuoconstructional abilities. The term "mild cognitive impairment" was adopted by Petersen in 2004 to describe a period in the course of neurodegenerative disease where cognition is no longer normal relative to age expectations, however, daily functions are not sufficiently disrupted to correlate with the diagnosis of dementia. Most of the literature refers to the amnestic form of MCI, which is likely a precursor of AD. The rate of conversion from amnestic form of MCI to AD is estimated to reach 10-15% per year. That is why MCI generated a great deal of research. When considering MCI a precursor of AD, it seems reasonable to study AD genetic markers in the MCI patients. In AD, association studies focus on genetic polymorphisms assumed to have an effect on the expression and modulation function of genes associated with AD pathogenesis (ApoE, APP, presenilin 1, presenilin 2, tau protein), and on polymorphisms related to metabolism of the aforementioned proteins (splicing, degradation). Neuropsychological assesment plays a substantial role in the diagnosis of MCI, especially in the case of identification of different MCI subtypes or typical profiles of cognitive performance in prodromal phases of neurodegenerative diseases. The optimal composition of diet may increase an average age and prevent impairment of cognitive functions at the same time. Despite the progress in early diagnosis of MCI and dementia, further research is needed on differential diagnosis and treatment.

Citovat

JANOUTOVÁ, Jana, Omar ŠERÝ, Ladislav HOSÁK and Vladimír JANOUT. Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review. Central European Journal of Public Health. Tigis s.r.o., 2015, vol. 23, No 4, p. 365-367. ISSN 1210-7778.

@article{1338060,
   author = {Janoutová, Jana and Šerý, Omar and Hosák, Ladislav and Janout, Vladimír},
   article_number = {4},
   keywords = {mild cognitive impairment; Alzheimer’s dementia; terminology; genetics; neuropsychological testing; secondary prevention},
   language = {eng},
   issn = {1210-7778},
   journal = {Central European Journal of Public Health},
   note = {Nepřenášet do RIV, Omar Šerý nemá afiliaci na MU, respektive žádný z autorů nemá na WoS afiliaci na MU!},
   title = {Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review},
   volume = {23},
   year = {2015}
}

TY  - JOUR
ID  - 1338060
AU  - Janoutová, Jana - Šerý, Omar - Hosák, Ladislav - Janout, Vladimír
PY  - 2015
TI  - Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review
JF  - Central European Journal of Public Health
VL  - 23
IS  - 4
SP  - 365-367
EP  - 365-367
PB  - Tigis s.r.o.
SN  - 12107778
N1  - Nepřenášet do RIV, Omar Šerý nemá afiliaci na MU, respektive žádný z autorů nemá na WoS afiliaci na MU!
KW  - mild cognitive impairment
KW  - Alzheimer’s dementia
KW  - terminology
KW  - genetics
KW  - neuropsychological testing
KW  - secondary prevention
N2  - Mild Cognitive Impairment (MCI) may be a precursor of Alzheimer's disease (AD). There is a boundary area between normal aging and dementia. In practice, the term "age related cognitive decline" has been used interchangeably with "normal aging". Alternatively, the term "aging associated cognitive decline" was introduced and defined by a performance on a standardized cognitive scale focused on learning and memory, attention and cognitive speed, language, or visuoconstructional abilities. The term "mild cognitive impairment" was adopted by Petersen in 2004 to describe a period in the course of neurodegenerative disease where cognition is no longer normal relative to age expectations, however, daily functions are not sufficiently disrupted to correlate with the diagnosis of dementia. Most of the literature refers to the amnestic form of MCI, which is likely a precursor of AD. The rate of conversion from amnestic form of MCI to AD is estimated to reach 10-15% per year. That is why MCI generated a great deal of research. When considering MCI a precursor of AD, it seems reasonable to study AD genetic markers in the MCI patients. In AD, association studies focus on genetic polymorphisms assumed to have an effect on the expression and modulation function of genes associated with AD pathogenesis (ApoE, APP, presenilin 1, presenilin 2, tau protein), and on polymorphisms related to metabolism of the aforementioned proteins (splicing, degradation). Neuropsychological assesment plays a substantial role in the diagnosis of MCI, especially in the case of identification of different MCI subtypes or typical profiles of cognitive performance in prodromal phases of neurodegenerative diseases. The optimal composition of diet may increase an average age and prevent impairment of cognitive functions at the same time. Despite the progress in early diagnosis of MCI and dementia, further research is needed on differential diagnosis and treatment.
ER  -

JANOUTOVÁ, Jana, Omar ŠERÝ, Ladislav HOSÁK and Vladimír JANOUT. Is Mild Cognitive Impairment a Precursor of Alzheimer's Disease? Short Review. \textit{Central European Journal of Public Health}. Tigis s.r.o., 2015, vol.~23, No~4, p.~365-367. ISSN~1210-7778.

Detailed Information on Publication Record