Does the parasite-mediated selection drive the MHC class IIB
diversity in wild populations of European chub (Squalius
cephalus)?

J 2016

Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ a Andrea VETEŠNÍKOVÁ ŠIMKOVÁ

Základní údaje

Originální název

Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?

Autoři

SEIFERTOVÁ, Mária (703 Slovensko, domácí), Jiří JARKOVSKÝ (203 Česká republika, garant, domácí) a Andrea VETEŠNÍKOVÁ ŠIMKOVÁ (203 Česká republika, domácí)

Vydání

Parasitology Research, New York, Springer, 2016, 0932-0113

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10600 1.6 Biological sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.329

Kód RIV

RIV/00216224:14310/16:00087838

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1007/s00436-015-4874-4

UT WoS

000372907300005

Klíčová slova anglicky

Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites

Štítky

AKR, EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 28. 2. 2018 15:24, Mgr. Mária Seifertová, Ph.D.

Anotace

V originále

The genes of major histocompatibility complex (MHC) provide an excellent opportunity to study host-parasite relationships because they are expected to evolve in response to parasites, and variation in parasite communities. In this study, we investigated the potential role of parasite-mediated selection acting on MHC class IIB (DAB) genes in European chub (Squalius cephalus) natural populations. We found significant differences between populations in metazoan parasites, neutral and adaptive genetic diversities. The analyses based on pairwise data revealed that populations with dissimilar MHC allelic profiles were geographically distant populations with significantly different diversity in microsatellites and a dissimilar composition of parasite communities. The results from the generalized estimating equations method (GEE) on the level of individuals revealed that metazoan parasite load in European chub was influenced by the diversity of DAB alleles as well as by the diversity of neutral genetic markers and host traits reflecting condition and immunocompetence. The multivariate co-inertia analysis (COIA) showed specific associations between DAB alleles and parasite species. DAB1-like alleles were more involved in associations with ectoparasites, while DAB3-like alleles were positively associated with endoparasites which could suggest potential differences between DAB genes caused by different selection pressure. Our study revealed that parasite-mediated selection is not the only variable affecting MHC diversity in European chub; however, we strongly support the role of neutral processes as the main driver of DAB diversity across populations. In addition, our study contributes to the understanding of the evolution of MHC genes in wild living fish.

Návaznosti

GA524/07/0188, projekt VaV

Název: Úloha imunitní investice v kontextu kompromisů: imunoekologické studium vztahů mezi reprodukcí, imunitou a parazitizmem u sladkovodních ryb

Investor: Grantová agentura ČR, Úloha imunitní investice v kontextu kompromisů: imunoekologické studium vztahů mezi reprodukcí, imunitou a parazitizmem u sladkovodních ryb

GBP505/12/G112, projekt VaV

Název: ECIP - Evropské centrum ichtyoparazitologie

Investor: Grantová agentura ČR, ECIP - Evropské centrum ichtyoparazitologie

Citovat

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ a Andrea VETEŠNÍKOVÁ ŠIMKOVÁ. Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)? Parasitology Research. New York: Springer, 2016, roč. 115, č. 4, s. 1401-1415. ISSN 0932-0113. Dostupné z: https://dx.doi.org/10.1007/s00436-015-4874-4.

@article{1338650,
   author = {Seifertová, Mária and Jarkovský, Jiří and Vetešníková Šimková, Andrea},
   article_location = {New York},
   article_number = {4},
   doi = {http://dx.doi.org/10.1007/s00436-015-4874-4},
   keywords = {Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites},
   language = {eng},
   issn = {0932-0113},
   journal = {Parasitology Research},
   title = {Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?},
   volume = {115},
   year = {2016}
}

TY  - JOUR
ID  - 1338650
AU  - Seifertová, Mária - Jarkovský, Jiří - Vetešníková Šimková, Andrea
PY  - 2016
TI  - Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)?
JF  - Parasitology Research
VL  - 115
IS  - 4
SP  - 1401-1415
EP  - 1401-1415
PB  - Springer
SN  - 09320113
KW  - Major histocompatibility complex Metazoan parasites Parasite-driven balancing selection Genetic diversity Phylogeography Microsatellites
N2  - The genes of major histocompatibility complex (MHC) provide an excellent opportunity to study host-parasite relationships because they are expected to evolve in response to parasites, and variation in parasite communities. In this study, we investigated the potential role of parasite-mediated selection acting on MHC class IIB (DAB) genes in European chub (Squalius cephalus) natural populations. We found significant differences between populations in metazoan parasites, neutral and adaptive genetic diversities. The analyses based on pairwise data revealed that populations with dissimilar MHC allelic profiles were geographically distant populations with significantly different diversity in microsatellites and a dissimilar composition of parasite communities. The results from the generalized estimating equations method (GEE) on the level of individuals revealed that metazoan parasite load in European chub was influenced by the diversity of DAB alleles as well as by the diversity of neutral genetic markers and host traits reflecting condition and immunocompetence. The multivariate co-inertia analysis (COIA) showed specific associations between DAB alleles and parasite species. DAB1-like alleles were more involved in associations with ectoparasites, while DAB3-like alleles were positively associated with endoparasites which could suggest potential differences between DAB genes caused by different selection pressure. Our study revealed that parasite-mediated selection is not the only variable affecting MHC diversity in European chub; however, we strongly support the role of neutral processes as the main driver of DAB diversity across populations. In addition, our study contributes to the understanding of the evolution of MHC genes in wild living fish.
ER  -

SEIFERTOVÁ, Mária, Jiří JARKOVSKÝ a Andrea VETEŠNÍKOVÁ ŠIMKOVÁ. Does the parasite-mediated selection drive the MHC class IIB diversity in wild populations of European chub (Squalius cephalus)? \textit{Parasitology Research}. New York: Springer, 2016, roč.~115, č.~4, s.~1401-1415. ISSN~0932-0113. Dostupné z: https://dx.doi.org/10.1007/s00436-015-4874-4.

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