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@article{1338723, author = {Humpolíček, Petr and Radaszkiewicz, Katarzyna Anna and Kašpárková, Věra and Stejskal, Jaroslav and Trchová, Miroslava and Kuceková, Zdenka and Vičarová, Hana and Pacherník, Jiří and Lehocký, Marián and Minařík, Antonín and Pacherník, Jiří}, article_location = {Cambridge}, article_number = {84}, doi = {http://dx.doi.org/10.1039/C5RA12218J}, keywords = {Polyaniline; stem cells}, language = {eng}, issn = {2046-2069}, journal = {RSC Advances}, title = {Stem Cell Differentiation on Conducting Polyaniline}, url = {http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA12218J#!divAbstract}, volume = {5}, year = {2015} }
TY - JOUR ID - 1338723 AU - Humpolíček, Petr - Radaszkiewicz, Katarzyna Anna - Kašpárková, Věra - Stejskal, Jaroslav - Trchová, Miroslava - Kuceková, Zdenka - Vičarová, Hana - Pacherník, Jiří - Lehocký, Marián - Minařík, Antonín - Pacherník, Jiří PY - 2015 TI - Stem Cell Differentiation on Conducting Polyaniline JF - RSC Advances VL - 5 IS - 84 SP - 68796-68805 EP - 68796-68805 PB - Royal Society of Chemistry SN - 20462069 KW - Polyaniline KW - stem cells UR - http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA12218J#!divAbstract L2 - http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA12218J#!divAbstract N2 - Polyaniline is a promising conducting polymer with broad application potential in biomedicine. Its medical use, however, requires both biocompatibility and suitable physico-chemical and surface properties. The microstructure, electrical properties, and surface characteristics of polyaniline salt, polyaniline base, and polyaniline deposited with biologically active poly(2-acrylamido-2-methyl-1-propanesulfonic acid) were revealed using atomic force microscopy, contact angle measurements, and Raman spectroscopy. As conducting polymers can be preferentially applied in tissue engineering of heart and nervous tissues, the cardiomyogenesis in pure cardiomyocytes derived from embryonic stem cells and neurogenesis in neural progenitors isolated from embryonal 13 dpc brain were further investigated. The results show that neither cardiomyogenesis nor neurogenesis were influenced by any of the tested polyaniline films. However, the most favorable cell behaviour was observed on pristine polyaniline base; therefore, polyaniline in pristine forms without any further modification can be applied in a variety of biomedical fields. ER -
HUMPOLÍČEK, Petr, Katarzyna Anna RADASZKIEWICZ, Věra KAŠPÁRKOVÁ, Jaroslav STEJSKAL, Miroslava TRCHOVÁ, Zdenka KUCEKOVÁ, Hana VIČAROVÁ, Jiří PACHERNÍK, Marián LEHOCKÝ a Antonín MINAŘÍK. Stem Cell Differentiation on Conducting Polyaniline. \textit{RSC Advances}. Cambridge: Royal Society of Chemistry, 2015, roč.~5, č.~84, s.~68796-68805. ISSN~2046-2069. Dostupné z: https://dx.doi.org/10.1039/C5RA12218J.
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