2015
Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering
ŠVACHOVÁ, Veronika; Lucy VOJTOVÁ; Veronika SEDLÁKOVÁ; Aleš HAMPL; David PAVLIŇÁK et. al.Basic information
Original name
Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering
Name in Czech
Hydrolyticky stabilní želatinová nanovlákna modifikovaná oxidovanou celulózou s využitím v tkáňovém inženýrství
Authors
ŠVACHOVÁ, Veronika (203 Czech Republic, guarantor); Lucy VOJTOVÁ (203 Czech Republic); Veronika SEDLÁKOVÁ (203 Czech Republic, belonging to the institution); Aleš HAMPL (203 Czech Republic, belonging to the institution) and David PAVLIŇÁK (203 Czech Republic, belonging to the institution)
Edition
2015
Other information
Language
English
Type of outcome
Conference abstract
Field of Study
10305 Fluids and plasma physics
Country of publisher
Czech Republic
Confidentiality degree
is not subject to a state or trade secret
References:
RIV identification code
RIV/00216224:14310/15:00086961
Organization unit
Faculty of Science
ISBN
978-80-214-5228-2
Keywords in English
Nanospider;nanofibers;gelatin;crosslinking;oxidized cellulose
Tags
Changed: 28/4/2016 15:38, Ing. Andrea Mikešková
Abstract
In the original language
The present work deals with the preparation of (bio) polymer nanofibers by Nanospider technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the structure of the extracellular matrix forming the structure of tissues. Gelatin nanofibers modified by addition of sodium or calcium salt of oxidized cellulose were successfully prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal efficiency. Crosslinking process was an another important step to improve hydrolytic stability and mechanical properties of nanofibers. H441 cell lines (human papillary adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns).
Links
| ED2.1.00/03.0086, research and development project |
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| LO1411, research and development project |
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