Další formáty:
BibTeX
LaTeX
RIS
@article{1339332, author = {Samadder, Pounami and Aithal, Rakesh and Beláň, Ondrej and Krejčí, Lumír}, article_location = {Kidlington}, article_number = {"May"}, doi = {http://dx.doi.org/10.1016/j.pharmthera.2016.02.007}, keywords = {DSB repair; genome instability; cancer; kinases; helicases; nucleases}, language = {eng}, issn = {0163-7258}, journal = {Pharmacology & Therapeutics}, title = {Cancer TARGETases: DSB Repair as a Pharmacological Target}, url = {http://www.sciencedirect.com/science/article/pii/S016372581600036X}, volume = {161}, year = {2016} }
TY - JOUR ID - 1339332 AU - Samadder, Pounami - Aithal, Rakesh - Beláň, Ondrej - Krejčí, Lumír PY - 2016 TI - Cancer TARGETases: DSB Repair as a Pharmacological Target JF - Pharmacology & Therapeutics VL - 161 IS - "May" SP - 111-131 EP - 111-131 PB - Pergamon-Elsevier Science LTD SN - 01637258 KW - DSB repair KW - genome instability KW - cancer KW - kinases KW - helicases KW - nucleases UR - http://www.sciencedirect.com/science/article/pii/S016372581600036X N2 - Cancer is a disease attributed to the accumulation of DNA damages due to incapacitation of DNA repair pathways resulting in genomic instability and a mutator phenotype. Among the DNA lesions, double stranded breaks (DSBs) are the most toxic forms of DNA damage which may arise as a result of extrinsic DNA damaging agents or intrinsic replication stress in fast proliferating cancer cells. Accurate repair of DSBs are therefore paramount to the cell survival, and several classes of proteins such as kinases, nucleases, helicases or core recombinational proteins have pre-defined jobs in precise execution of DSB repair pathways. On one hand, the proper functioning of these proteins ensures maintenance of genomic stability in normal cells, and on the other hand results in resistance to various drugs employed in cancer therapy and therefore present a suitable opportunity for therapeutic targeting. Higher relapse and resistance in cancer patients due to non-specific, cytotoxic therapies is an alarming situation and it is becoming more evident to employ personalized treatment based on the genetic landscape of the cancer cells. For the success of personalized treatment, it is of immense importance to identify more suitable targetable proteins in DSB repair pathways and also to explore new synthetic lethal interactions with these pathways. Here we review the various alternative approaches to target the various protein classes termed as cancer TARGETases in DSB repair pathway to obtain more beneficial and selective therapy. ER -
SAMADDER, Pounami, Rakesh AITHAL, Ondrej BELÁŇ a Lumír KREJČÍ. Cancer TARGETases: DSB Repair as a Pharmacological Target. \textit{Pharmacology \&{} Therapeutics}. Kidlington: Pergamon-Elsevier Science LTD, 2016, roč.~161, ''May'', s.~111-131. ISSN~0163-7258. Dostupné z: https://dx.doi.org/10.1016/j.pharmthera.2016.02.007.
|