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@article{1339374,
author = {Gurianova, Veronika and Stroy, Dmytro and Ciccocioppo, Rachele and Gasparova, Iveta and Petrovic, Daniel and Souček, Miroslav and Dosenko, Victor and Kružliak, Peter},
article_location = {Hoboken},
article_number = {8},
doi = {http://dx.doi.org/10.1002/cbf.3151},
keywords = {miRNAs biogenesis; stress response; hub-mechanisms; cardiac pathophysiology},
language = {eng},
issn = {0263-6484},
journal = {CELL BIOCHEMISTRY AND FUNCTION},
title = {Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart},
volume = {33},
year = {2015}
}
TY - JOUR
ID - 1339374
AU - Gurianova, Veronika - Stroy, Dmytro - Ciccocioppo, Rachele - Gasparova, Iveta - Petrovic, Daniel - Souček, Miroslav - Dosenko, Victor - Kružliak, Peter
PY - 2015
TI - Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart
JF - CELL BIOCHEMISTRY AND FUNCTION
VL - 33
IS - 8
SP - 509-518
EP - 509-518
PB - Wiley-Blackwell
SN - 02636484
KW - miRNAs biogenesis
KW - stress response
KW - hub-mechanisms
KW - cardiac pathophysiology
N2 - MicroRNAs (miRNAs) are important regulators of heart function and then an intriguing therapeutic target for plenty of diseases. The problem raised is that many data in this area are contradictory, thus limiting the use of miRNA-based therapy. The goal of this review is to describe the hub-mechanisms regulating the biogenesis and function of miRNAs, which could help in clarifying some contradictions in the miRNA world. With this scope, we analyse an array of factors, including several known agents of stress response, mediators of epigenetic changes, regulators of alternative splicing, RNA editing, protein synthesis and folding and proteolytic systems. All these factors are important in cardiovascular function and most of them regulate miRNA biogenesis, but their influence on miRNAs was shown for non-cardiac cells or some specific cardiac pathologies. Finally, we consider that studying the stress response factors, which are upstream regulators of miRNA biogenesis, in the diseased heart could help in (1) explaining some contradictions concerning miRNAs in heart pathology, (2) making the role of miRNAs in pathogenesis of cardiovascular disease more clear, and therefore, (3) getting powerful targets for its molecular therapy.
ER -
GURIANOVA, Veronika, Dmytro STROY, Rachele CICCOCIOPPO, Iveta GASPAROVA, Daniel PETROVIC, Miroslav SOUČEK, Victor DOSENKO a Peter KRUŽLIAK. Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart. \textit{CELL BIOCHEMISTRY AND FUNCTION}. Hoboken: Wiley-Blackwell, 2015, roč.~33, č.~8, s.~509-518. ISSN~0263-6484. Dostupné z: https://dx.doi.org/10.1002/cbf.3151.
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